Release mechanisms from gentamicin loaded poly(lactic-co-glycolic acid) (PLGA) microparticles
Release mechanisms from gentamicin loaded poly(lactic-co-glycolic acid) (PLGA) microparticles
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DOI：
10.1002/jps.10012
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发表时间：
2002-03-01
影响因子：
3.8
通讯作者：
Schlapp, M
中科院分区：
文献类型：
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作者：
Friess, WF;Schlapp, M
为了基于生物可降解系统提供持续1周的局部庆大霉素递送，利用Resomer RG 502 H（13.5 kD的未封端品种）和Resomer RG 503（36.2 kD的封端聚合物）的50/50共混物开发聚（乳酸-共-乙醇酸）（PLGA）微粒。通过形态变化分析和热分析，重点研究了聚合物的玻璃化转变温度（T-g）和力学性能的释放机制。庆大霉素的释放与达到临界分子量的颗粒的结构分解有关。T-g为
To provide local gentamicin delivery for 1 week based on a biodegradable system, poly(lactic-co-glycolic acid) (PLGA) microparticles were developed utilizing a 50/50 blend of Resomer(R) RG 502H, an uncapped variety of 13.5 kD, and Resomer(R) RG 503, an endcapped polymer of 36.2 kD. The liberation mechanism was investigated by analysis of morphological changes and thermal analysis focusing on the polymer glass transition temperature (T-g) and the mechanical properties. The release of gentamicin was related to a structural breakdown of the particles reaching a critical molecular weight. A T-g of