Autologous transplantation of bone marrow-derived mesenchymal stem cells: a promising therapeutic strategy for prevention of skin-graft contraction
Autologous transplantation of bone marrow-derived mesenchymal stem cells: a promising therapeutic strategy for prevention of skin-graft contraction
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DOI：
10.1111/j.1365-2230.2011.04260.x
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发表时间：
2012-07-01
影响因子：
4.1
通讯作者：
Fu, X.
中科院分区：
文献类型：
--
作者：
Xu, Y.;Huang, S.;Fu, X.
增生性瘢痕是由严重烧伤后的异常愈合引起的，其特征是皮肤原有结构和功能的丧失。自体皮肤移植是疤痕切除后的首选治疗方法，然而，移植物内会不可避免地出现一定程度的收缩。据我们所知，这是非常罕见的骨髓间充质干细胞（BM-MSCs）已用于治疗皮肤移植收缩。然而，在我们的诊所中，我们发现在2年的随访分析中，用自体BM-MSCs联合移植分割皮肤治疗的区域比单独用皮肤移植治疗的区域更不可能有皮肤移植物的收缩。这一结果表明，骨髓间充质干细胞可能是一个潜在的和有前途的治疗，以防止皮肤移植收缩。
Hypertrophic scars resutl from abnormal healing of severe burns, and are characterized by loss of the original structure and function of the skin. Transplantation of autologous split skin is the preferred treatment after scar excision; however, there will be some unavoidable degree of contraction within the grafts. To our knowledge, it is very rare that bone marrow-derived mesenchymal stem cells (BM-MSCs) have been used for the treatment of skin-graft contraction. However, in our clinics, we found that during a 2-year follow-up analysis, areas treated with autologous BM-MSCs combined with transplantation of split skin were less likely to have contraction of the skin grafts than areas treated with skin grafts alone. This result indicates that BM-MSCs may be a potential and promising treatment to prevent contraction of skin grafts.