Effects of antipsychotic and antidepressant drugs on action monitoring in healthy volunteers
Effects of antipsychotic and antidepressant drugs on action monitoring in healthy volunteers
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DOI：
10.1016/j.brainres.2006.01.006
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发表时间：
2006-08-11
期刊：
影响因子：
2.9
通讯作者：
Verkes, Robbert J.
中科院分区：
文献类型：
--
作者：
de Bruijn, Ellen R. A.;Sabbe, Bernard G. C.;Verkes, Robbert J.
人类需要持续监控自己的行为，以尽快发现错误，并调整自己的表现，以防止未来的错误。这种行为监控过程可以通过测量错误相关负性（ERN）来研究，这是错误发生后立即引发的ERP成分。在目前的研究中，我们研究了经典抗精神病药氟哌啶醇（2.5 mg）、非典型抗精神病药奥氮平（10 mg）和抗抑郁药帕罗西汀（20 mg）（一种选择性血清素再摄取抑制剂）给药后的行为监测。在随机、双盲、单剂量、四向交叉设计中，健康志愿者（N = 14）被给予三种化合物和安慰剂。所有参与者都完成了一个快速的双选项反应任务，同时获得了事件相关电位和行为测量。氟哌啶醇和奥氮平均可显著降低ERN振幅。服用帕罗西汀后，ERN与安慰剂无明显差异。N2一致性效应不受治疗条件的影响。只有奥氮平表现出行为效应，即反应减慢，错误率增加，以及缺乏表现调整。多巴胺拮抗剂氟哌啶醇后ern的减弱与多巴胺在动作监测中的作用一致。氟哌啶醇被认为阻断多巴胺能信号传导，从而降低ERN振幅。另一方面，奥氮平的影响主要是由其镇静副作用引起的，导致动机和错误评价下降。最后，帕罗西汀后没有任何影响，表明血清素的传递在与动作监测相关的调节机制中没有直接作用。(c) 2006 Elsevier B.V.版权所有
Humans need to monitor their actions continuously to detect errors as fast as possible and to adjust their performance to prevent future errors. This process of action monitoring can be investigated by measuring the error-related negativity (ERN), an ERP component elicited immediately after an error. In the current study, we investigated action monitoring after administration of the classic antipsychotic haloperidol (2.5 mg), the atypical antipsychotic olanzapine (10 mg), and the antidepressant paroxetine (20 mg), a selective serotonin reuptake inhibitor. Healthy volunteers (N = 14) were administered the three compounds and placebo in a randomized, double-blind, single-dose, four-way cross-over design. All participants performed a speeded two-choice reaction task, while event-related potentials and behavioral measurements were obtained. Both haloperidol and olanzapine significantly reduced ERN amplitudes. After paroxetine, the ERN was not different from placebo. N2 congruency effects were not affected by treatment condition. Only olanzapine demonstrated behavioral effects, namely a slowing of responses, an increase in error rates, and the absence of performance adjustments. The attenuated ERNs after the dopamine antagonist haloperidol are in line with the presumed role of dopamine in action monitoring. Haloperidol is thought to block dopaminergic signaling, thus reducing ERN amplitudes. On the other hand, the effects of olanzapine are mainly caused by its sedative side effects, leading to a decline in motivation and appraisal of errors. Finally, the absence of any effects after paroxetine suggests that serotonin transmission does not play a direct role in regulating mechanisms related to action monitoring. (c) 2006 Elsevier B.V. All rights reserved.