Transmission Clustering Drives the Onward Spread of the HIV Epidemic Among Men Who Have Sex With Men in Quebec
Transmission Clustering Drives the Onward Spread of the HIV Epidemic Among Men Who Have Sex With Men in Quebec
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DOI：
10.1093/infdis/jir468
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发表时间：
2011-10-01
影响因子：
6.4
通讯作者：
Wainberg, Mark A.
中科院分区：
文献类型：
--
作者：
Brenner, Bluma G.;Roger, Michel;Wainberg, Mark A.
系统动力学分析和流行病学数据确定了男男性行为者中原发性人类免疫缺陷病毒1型感染（PHI）的3种传播模式（2001-2009年）：420个独特的PHI，102个小簇（每个簇2-4个PHI，n = 280）和46个大簇（每个簇5-31个PHI，n = 5 450）。大型集群不成比例地从2005年的25.2%增加到2009年的39.1%（chi（2）= 33.9，P < .001）。11个月以上大集群的标量扩张（四分位距，3.5-25.5个月）与集群成员大小相关（r（2）= 0.174，F = 4.424，P = 0.047）。PHI队列数据揭示了3组人群的社交网络和危险行为的差异，表明需要有针对性的预防措施。
Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n 5 450). Large clusters disproportionately increased from 25.2% of PHIs in 2005 to 39.1% in 2009 (chi(2) = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-25.5 months) correlated with cluster membership size (r(2) = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures.