RESPONSE OF SWINE SKIN MICROVASCULATURE TO ACUTE SINGLE EXPOSURES OF X-RAYS - QUANTIFICATION OF ENDOTHELIAL CHANGES
RESPONSE OF SWINE SKIN MICROVASCULATURE TO ACUTE SINGLE EXPOSURES OF X-RAYS - QUANTIFICATION OF ENDOTHELIAL CHANGES
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DOI：
10.2307/3576049
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发表时间：
1984-01-01
影响因子：
3.4
通讯作者：
FAJARDO, LF
中科院分区：
文献类型：
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作者：
ARCHAMBEAU, JO;INES, A;FAJARDO, LF
2300r的急性单次x射线暴露会在猪皮肤中产生湿润反应（溃疡），在17天出现，32天愈合，并可能在42至70天之间再次分解。最初的研究量化了这70天期间表皮种群密度的变化。密度变化发生在真皮微血管内皮细胞群量化。当基础种群在24天后下降到10%的最低点时，内皮种群保持在控制水平。超过24天，内皮细胞密度突然下降到50%，表皮细胞密度恢复到控制水平，在32天超过20%。随后，两个种群在57天后减少到0。内皮细胞的损失与血管管腔密度的减少相似。最初的湿润反应显然是由辐射引起的表皮细胞的损失引起的，而第二个反应是由皮肤微血管的损失引起的。
An acute single X-ray exposure of 2300 R produces in swine skin a moist reaction (ulceration) that appears at 17 days, heals by 32 days and may break down again between 42 and 70 days. Initial studies quantified the epidermal population density changes during this 70-day period. The density changes occurring in the endothelial cell population of the dermal microvasculature were quantified. While the basal population decreases to a nadir of 10% control by 24 days, the endothelial population remains at control levels. Beyond 24 days, the endothelial cell density decreases abruptly to 50% as the epidermal cell density returns to control levels and overshoots by 20% at 32 days. Subsequently, both populations decrease to 0 by 57 days. Endothelial cell loss parallels a similar decrease in vascular lumen density. The initial moist reaction evidently results from a radiation-induced loss of epidermal cells, while the 2nd reaction results from the loss of dermal microvasculature.