Reduction of Overall Helicobacter pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus johnsonii La1 (LC1) and Its in Vitro Activities against H. pylori Motility and Adherence
Reduction of Overall Helicobacter pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus johnsonii La1 (LC1) and Its in Vitro Activities against H. pylori Motility and Adherence
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DOI：
10.1271/bbb.110921
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发表时间：
2012-04
期刊：
影响因子：
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通讯作者：
Hirokazu Isobe;A. Nishiyama;Tomomi Takano;W. Higuchi;S. Nakagawa;I. Taneike;Y. Fukushima;Tatsuo Yamamoto
中科院分区：
文献类型：
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作者：
Hirokazu Isobe;A. Nishiyama;Tomomi Takano;W. Higuchi;S. Nakagawa;I. Taneike;Y. Fukushima;Tatsuo Yamamoto
研究了约氏乳杆菌 La1 (LC1) 对胃中幽门螺杆菌定植的影响。接种 LC1 的蒙古沙鼠中的幽门螺杆菌定植和胃炎明显低于对照动物。 LC1 培养上清液（>10-kDa 分数）抑制幽门螺杆菌运动并诱导人胃上皮细胞中的细菌聚集，表明 LC1 产品的临床应用潜力。
The effects of Lactobacillus johnsonii La1 (LC1) on Helicobacter pylori colonization in the stomach were investigated. H. pylori colonization and gastritis in LC1-inoculated Mongolian gerbils were significantly less intense than those in the control animals. LC1 culture supernatant (>10-kDa fraction) inhibited H. pylori motility and induced bacterial aggregation in human gastric epithelial cells, suggesting the potential of clinical use of LC1 product.