Plasma sphingomyelin is not associated with microvascular changes in the retina.
Plasma sphingomyelin is not associated with microvascular changes in the retina.
复制标题
血浆鞘磷脂与视网膜微血管变化无关。
DOI：
10.1016/j.mvr.2007.07.002
复制
发表时间：
2008
影响因子：
3.1
通讯作者：
Wong,TienYin
中科院分区：
文献类型：
--
作者：
Cheung,Ning;Islam,FMAmirul;Klein,Ronald;Klein,BarbaraEK;Wong,TienYin
Plasma sphingomyelin has been proposed to be a novel biomarker for cardiovascular disease (Jiang et al., 2000). Evidence from experimental, animal, and human studies supports its potential pathogenic role in the development of large artery atherosclerotic disease (Tabas, 2004) However, whether it also exerts adverse effects on the microcirculation (eg, arterioles) is unknown. To test this hypothesis, we examined, in the Multi-Ethnic Study of Atherosclerosis (MESA), the associations between plasma sphingomyelin and retinal microvascular changes that have been previously identified as independent predictors of future cardiovascular disease (Wong et al., 2004).Of the 6,814 MESA participants at the first examination (2000–2), when plasma sphingomyelin levels were measured (Nelson et al., 2006), 6,147 participants returned at the second examination (2002–4) for fundus photography (Wong et al., 2006). Of these, we excluded those without gradable retinal photographs or sphingomyelin data, leaving 6,056 participants for our current analysis. Retinal vascular calibers were measured by a computer-based program using a previously validated protocol (Wong et al., 2006). For each photograph, all retinal arterioles and venules coursing through an area of half to one optic disc diameter from the optic disc margin were measured and summarized as the central retinal arteriolar and venular equivalents, which represented the averaged projected caliber for the central retinal vessels. We also graded retinopathy signs based on the Early Treatment of Diabetic Retinopathy Study severity scale.
