Visible-Light-Mediated Dehydrogenative Cross-Coupling: Synthesis of Nonsymmetrical Atropisomeric Biaryls
Visible-Light-Mediated Dehydrogenative Cross-Coupling: Synthesis of Nonsymmetrical Atropisomeric Biaryls
复制标题
可见光介导的脱氢交叉偶联：非对称阻转异构联芳基化合物的合成
DOI：
10.1002/ajoc.201700242
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发表时间：
2017
影响因子：
2.7
通讯作者：
Xia Wujiong
中科院分区：
文献类型：
--
作者：
Wang Junlei;Zhao Yating;Gao Han;Gao Guo-Lin;Yang Chao;Xia Wujiong
描述了在室温下使用蓝光LED照射的光催化剂，2-萘胺/2-萘酚衍生物与苯胺/苯酚衍生物的直接交叉偶联反应，用于制备非对称阻转异构联芳基化合物，特别是BINOL型联芳基化合物。该方案提供了一种高效、简便、高产率的非对称阻转异构联芳化合物的合成方法，该类化合物广泛存在于天然产物中，对材料化学有重要的应用价值。
The direct cross‐dehydrogenative coupling reactions of 2‐naphthylamine/2‐naphthol derivatives with aniline/phenol derivatives for the preparation of nonsymmetrical atropisomeric biaryl compounds, especially BINOL‐type biaryls, using a photocatalyst with irradiation under blue LEDs at room temperature, are described. This protocol provides efficient and simple access to nonsymmetrical atropisomeric biaryls in good yields, which are often found in natural products and are useful for materials chemistry.