The role of free radicals and antioxidants: how do we know that they are working?
The role of free radicals and antioxidants: how do we know that they are working?
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DOI：
10.1080/10408399509527683
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发表时间：
1995
影响因子：
10.2
通讯作者：
Michael J. Thomas
中科院分区：
文献类型：
--
作者：
Michael J. Thomas
本文简要讨论了自由基是如何形成的，以及自由基在疾病中的可能参与。综述了基本的自由基反应和由细胞成分的自由基反应形成的产物类型。在许多情况下，体内自由基氧化可以通过测量自由基反应产生的产物来检测。由于有氧生物在氧代谢过程中产生含氧自由基，它们携带的化学物质和酶可以减少这些自由基造成的威胁。文章中描述了体内自由基的更常见来源以及细胞保护自身免受自由基损伤的方法。体内自由基的产生也可能是暴露于环境中存在的某些化学试剂的结果。这些药剂中的许多通过引发自由基反应而对暴露的组织和器官造成病理变化。
This review briefly discusses how free radicals are formed and the possible participation of free radicals in disease. The review describes the basic radical reactions and the types of products that are formed from the free-radical reactions of cellular constituents. In many cases, in vivo free-radical oxidation can be detected by measuring products that were derived from radical reactions. Since aerobic organisms generate oxygen-containing free radicals during oxygen metabolism, they carry chemicals and enzymes that reduce the threat posed by these radicals. The more common sources of in vivo free radicals are described in the article as well as the methods used by cells to protect themselves from free-radical damage. Generation of free radicals in vivo also may be the result of exposure to certain chemical agents present in the environment. Many of these agents cause pathologic changes to the exposed tissues and organs by initiating free-radical reactions.