A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio
A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio
复制标题
过氧化物酶体增殖物激活受体 α (PPAR α) 基因中的 Val227Ala 取代与非酒精性脂肪肝以及腰围和腰臀比减小相关
DOI：
10.1111/j.1440-1746.2008.05523.x
复制
发表时间：
2008-09-01
影响因子：
4.1
通讯作者：
Yu, Chaohui
中科院分区：
文献类型：
--
作者：
Chen, Shaohua;Li, Youming;Yu, Chaohui
背景与目的：本研究分析过氧化物酶体增殖物激活受体α (ppar - α) val227ala变异在非酒精性脂肪肝中的作用。方法：79例NAFLD患者和63例健康对照者作为研究对象。评估体重指数（BMI）、臀、腰、腰臀比（WHR）、血压（BP）、体脂百分比、总蛋白、白蛋白、ALT、甘油三酯、胆固醇、高密度脂蛋白（HDL）和空腹血糖。利用寡核苷酸芯片分析基因型。采用Logistic模型对所得数据进行多因素综合分析，筛选与ppar - α基因Val227Ala多态性密切相关的危险因素。结果：NAFLD患者CC/CT基因型（ala227ala和val227ala）占6.33% (5/79)，TT基因型（val227val）占93.67% (74/79)，CC/CT基因型占20.63% (13/63)，TT基因型占79.37%（50/63）。PPAR-alpha val227ala多态性在NAFLD和健康人之间的分布具有统计学意义（p = 0.011）。Val227Ala型受试者的体重、体质指数、臀围、腰围、腰臀比、体脂率、腹壁脂肪厚度均显著低于Val227wide型受试者。结果表明，腰围和腰高比与PPAR-alpha val227ala多态性相关。结论：ppar - α val227ala多态性可能参与NAFLD的发病过程，并在肥胖中发挥保护作用。
Background and Aim: This study analyzes the effect of the val227ala variant of the peroxisome proliferators-activated receptor-alpha (PPAR-alpha) on non-alcoholic fatty liver disease.Methods: 79 patients with NAFLD and 63 healthy counterparts were included in the study. Body mass index (BMI), hip, waist, waist-to-hip ratio (WHR), blood pressure (BP), the percentage of body fat, total protein, albumin, ALT, triglyceride, cholesterol, HDL and fasting blood glucose were assessed. The genotypes were analyzed using oligonucleotide microarray. Logistic model was used to perform the multi-factors synthetical analysis on the data obtained to screen the risk factors closely associated with Val227Ala polymorphism of PPAR-alpha gene.Results: There were 6.33% (5/79) subjects with CC/CT genotype (ala227ala and val227ala) and 93.67% (74/79) subjects with TT genotype (val227val) in patients with NAFLD, and there were 20.63% (13/63) with CC/CT genotype and 79.37% (50/63) subjects with TT genotype. The distribution of PPAR-alpha val227ala polymorphism between NAFLD and healty subjects was significant (p = 0.011). The level of weight, body mass index, hip circumference, waist circumference, waist-hip ratio, percentage of body fat, abdominal wall fat thickness in subjects with Val227Ala variant were significantly lower than that in Val227wide type. The results showed that waist circumference and WHR were related with the PPAR-alpha val227ala polymorphism.Conclusion: PPAR-alpha val227ala polymorphism may be involved in the pathogenesis of NAFLD and play a protective role in obesity.