ALLELIC LOSS OF CHROMOSOME 18Q AND PROGNOSIS IN COLORECTAL-CANCER
ALLELIC LOSS OF CHROMOSOME 18Q AND PROGNOSIS IN COLORECTAL-CANCER
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DOI：
10.1056/nejm199407283310401
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发表时间：
1994-07-28
影响因子：
158.5
通讯作者：
HAMILTON, SR
中科院分区：
文献类型：
--
作者：
JEN, J;KIM, HG;HAMILTON, SR
背景。在美国，每年大约有 150,000 人罹患结直肠癌。预后评估影响结直肠癌患者的治疗，包括辅助治疗的决定。我们评估了染色体 18q 等位基因丢失（一种与肿瘤进展相关的遗传事件）作为该疾病的预后标志物。方法。我们开发了利用微卫星标记和来自福尔马林固定、石蜡包埋肿瘤的 DNA 来检查 18q 染色体状态的程序。在 145 例连续切除的 II 期或 III 期结直肠癌中评估了 18q 染色体等位基因丢失。
Background. Colorectal cancer occurs in approximately 150,000 people each year in the United States. Prognostic assessment influences the treatment of patients with colorectal cancer, including decisions about adjuvant therapy. We evaluated chromosome 18q allelic loss, a genetic event associated with tumor progression, as a prognostic marker for this disease.Methods. We developed procedures to examine the status of chromosome 18q with microsatellite markers and DNA from formalin-fixed, paraffin-embedded tumors. Allelic loss of chromosome 18q was assessed in 145 consecutively resected stage II or III colorectal carcinomas.