Plasma protein displacement interactions are rarely of clinical significance.
Plasma protein displacement interactions are rarely of clinical significance.
复制标题
血浆蛋白置换相互作用很少具有临床意义。
DOI：
10.1159/000137256
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发表时间：
1979
期刊：
影响因子：
3.1
通讯作者：
E. Sellers
中科院分区：
文献类型：
--
作者：
E. Sellers
药物相互作用在频率和临床重要性方面通常被过分强调。据称基于从血浆蛋白中置换高度蛋白结合药物的相互作用尤其被误解，并且支持这种相互作用的证据通常不完整。在这些相互作用中，位移已被最令人信服地证明，并在临床上重要的后果envelope，一个额外的相互作用机制已经存在。从理论上讲，这种简单的位移相互作用不太可能是常见的、容易检测的或严重的。如果发生这种相互作用，它们将是短暂的。
Drug interactions in general have been overemphasized with respect to both frequency and clinical importance. Interactions allegedly based on displacement of highly protein-bound drugs from plasma proteins are particularly misunderstood and the evidence supporting such interaction is typically incomplete. In those interactions where displacement has been most convincingly shown and a clinically important consequence ensues, an additional interaction mechanism has been present. On theoretical grounds such simple displacement interactions are not likely to be common, easy to detect or serious. If such interactions occur they will be transient.