Recent advances in cell membrane chromatography for traditional Chinese medicines analysis
Recent advances in cell membrane chromatography for traditional Chinese medicines analysis
复制标题
细胞膜色谱法在中药分析中的最新进展
DOI：
10.1016/j.jpba.2014.05.021
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发表时间：
2014-12-01
影响因子：
3.4
通讯作者：
He, Langchong
中科院分区：
文献类型：
--
作者：
Hou, Xiaofang;Wang, Sicen;He, Langchong
传统中药（TCM）用于预防保健已有数千年的历史。活性成分是中药药效的基础，也是先导化合物的重要来源。细胞膜色谱（CMC）作为一种生物亲和色谱技术，自1996年发展至今已有近20年的历史。该方法已被证明是研究药物-受体相互作用和筛选中药活性成分的有效方法。在我们2007年的回顾中（药物发现。Ther.，1（2007）104-107），介绍了羧甲基纤维素固定相的制备、鉴定、评价和初步应用。本文综述了近年来CMC在仪器开发、药物-受体相互作用研究、中药活性成分筛选、中药质量控制等方面的最新进展和应用。(C)© 2014 Elsevier B. V.保留所有权利。
Traditional Chinese medicines (TCMs) have been used for preventative care for thousands of years. The active components are the basis for the pharmacodynamics of TCMs, and they can be an important source of lead compounds. As a bioaffinity chromatography technique, cell membrane chromatography (CMC) has been developed for almost 20 years since 1996. It has been proven to be a useful method for studying drug-receptor interactions and screening active components from medicinal herbs. In our review in 2007 (Drug Discov. Ther., 1 (2007) 104-107), the preparation, identification, evaluation, and preliminary applications of CMC stationary phases were presented. In this article, we briefly review some of the latest progress and applications about CMC including instrument development, research on drug-receptor interactions, screening active components from TCMs, and quality control of TCMs. (C) 2014 Elsevier B.V. All rights reserved.