Inhibition of experimental autoimmune uveoretinitis in rats by S‐antigen‐specific monoclonal antibodies
Inhibition of experimental autoimmune uveoretinitis in rats by S‐antigen‐specific monoclonal antibodies
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S抗原特异性单克隆抗体抑制大鼠实验性自身免疫性葡萄膜视网膜炎
DOI：
10.1002/eji.1830151108
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发表时间：
1985
影响因子：
5.4
通讯作者：
J. Faure
中科院分区：
文献类型：
--
作者：
Y. de Kozak;M. Mirshahi;C. Boucheix;J. Faure
当在免疫时腹膜内注射时，对视网膜S-自身抗原（S-Ag）具有特异性的IgG 2a或IgG 2b同种型的小鼠单克隆抗体（mAb）或大鼠抗S-Ag血清池可预防刘易斯大鼠的实验性自身免疫性葡萄膜视网膜炎。与S-Ag无关的相同同种型的对照mAb无抑制作用。通过酶联免疫吸附试验（使用大鼠κ链特异性小鼠mAb）研究，对S‐Ag的体液反应在抑制动物中中度但显著降低。使用小鼠κ链特异性大鼠mAb测量，注射mAb从大鼠血清中快速消失，可以通过其与炎症部位视网膜释放的自体抗原或抗独特型抗体复合来解释。
Mouse monoclonal antibodies (mAb), of either IgG2a or IgG2b isotypes, specific for the retinal S‐autoantigen (S‐Ag) or a pool of rat anti‐S‐Ag sera prevented experimental autoimmune uveoretinitis in Lewis rats when injected i.p. at the time of immunization. Control mAb of the same isotypes, irrelevant to S‐Ag, had no inhibitory effect. The humoral response to S‐Ag, as studied by enzyme‐linked immunosorbent assay using a mouse mAb specific for rat kappa chain, was moderately but significantly reduced in suppressed animals. The rapid disappearance of the injected mAb from rat sera, as measured using a rat mAb specific for mouse kappa chain, could be explained by its complexing with either autologous antigen released from the retina at the site of inflammation, or anti‐idiotypic antibodies.
葡萄膜炎患者血清牛视网膜抗原抗体水平。
影响因子：
4.4
作者：
Gregerson,DS;Abrahams,IW;Thirkill,CE
通讯作者：
Thirkill,CE