T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis.
T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis.
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T细胞对慢性类风湿关节炎中爱泼斯坦 - 巴尔病毒反式激活剂的反应。
DOI：
10.1084/jem.184.5.1791
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发表时间：
1996-11-01
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中科院分区：
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风湿性关节炎是一种多步骤的疾病与自身免疫功能的特点，但病因不明。根据一些间接观察，已经怀疑病毒如EB病毒（EBV）在类风湿性关节炎发病机制中的意义，但迄今为止，尚未提供EBV和类风湿性关节炎之间的直接联系。在这里，我们表明，一个大部分的T细胞浸润受影响的关节从慢性类风湿关节炎患者识别两个EBV反式激活因子（BZLF1和BMLF1）的主要组织相容性复合物限制的方式。从其他几个慢性类风湿性关节炎患者的滑膜淋巴细胞对这些EBV抗原的反应很容易检测到。因此，这些结果表明EBV对慢性类风湿性关节炎发病机制的直接贡献。它们还首次证明了针对EBV反式激活因子的T细胞应答的发生，这可能是控制病毒再激活的核心。
Rheumatoid arthritis is a multistep disorder associated with autoimmune features of yet unknown etiology. Implication of viruses such as Epstein-Barr virus (EBV) in rheumatoid arthritis pathogenesis has been suspected on the basis of several indirect observations, but thus far, a direct link between EBV and rheumatoid arthritis has not been provided. Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion. Responses to these EBV antigens by synovial lymphocytes from several other chronic rheumatoid arthritis patients were readily detectable. Thus these results suggest a direct contribution of EBV to chronic rheumatoid arthritis pathogenesis. They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation.