Phosphatidylinositol transfer proteins: the long and winding road to physiological function
Phosphatidylinositol transfer proteins: the long and winding road to physiological function
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DOI：
10.1016/s0962-8924(98)01281-1
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发表时间：
1998-07-01
影响因子：
19
通讯作者：
Bankaitis, VA
中科院分区：
文献类型：
--
作者：
Kearns, BG;Alb, JG;Bankaitis, VA
磷脂酰肌醇转移蛋白（PITP）历来被认为是通过在膜双层之间运输磷脂单体来帮助执行脂质分选事件。然而，最近的数据表明PITP在磷脂代谢与囊泡运输的协调和/或耦合以及信号转导反应的下调中发挥了意想不到的作用。我们现在才开始认识到PITP依赖的细胞反应的特性和PITP在真核细胞中执行其功能的有趣机制。
Phosphatidylinositol transfer proteins (PITPs) have historically been thought to help execute lipid-sorting events by transporting phospholipid monomers between membrane bilayers. Recent data, however, indicate unanticipated roles for PITPs in the coordination and/or coupling of phospholipid metabolism with vesicle trafficking and the downregulation of signal-transduction reactions. We are only now beginning to appreciate both the identities of PITP-dependent cellular reactions and the intriguing mechanisms by which PITPs execute their functions in eukaryotic cells.