Biomimetic Compartments Scaffolded by Nucleic Acid Nanostructures
Biomimetic Compartments Scaffolded by Nucleic Acid Nanostructures
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DOI：
10.1002/smll.201900256
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发表时间：
2019-06-01
期刊：
影响因子：
13.3
通讯作者：
Zhang, Ting
中科院分区：
文献类型：
--
作者：
Fu, Jinglin;Oh, Sung Won;Zhang, Ting
活细胞的行为受一系列受调控和限制的生化反应的支配。合成细胞反应器的设计和成功构建可以在广泛的应用中发挥作用，这将带来重大的科学和经济影响。在过去的几十年里，DNA自组装已经使复杂的1D，2D和3D纳米结构的设计和制造成为可能，并被应用于将各种生物分子组分组织成规定的2D和3D图案。在这个概念中，最近和令人兴奋的进展，在DNA支架的区室化及其在酶封装，脂质膜组装，人工跨膜纳米孔和智能药物递送中的应用是焦点。利用这些特性有望在实现新的合成和仿生反应器方面取得突破。
The behaviors of living cells are governed by a series of regulated and confined biochemical reactions. The design and successful construction of synthetic cellular reactors can be useful in a broad range of applications that will bring significant scientific and economic impact. Over the past few decades, DNA self-assembly has enabled the design and fabrication of sophisticated 1D, 2D, and 3D nanostructures, and is applied to organizing a variety of biomolecular components into prescribed 2D and 3D patterns. In this Concept, the recent and exciting progress in DNA-scaffolded compartmentalizations and their applications in enzyme encapsulation, lipid membrane assembly, artificial transmembrane nanopores, and smart drug delivery are in focus. Taking advantage of these features promises to deliver breakthroughs toward the attainment of new synthetic and biomimetic reactors.