A Phantom Study of Terahertz Spectroscopy and Imaging of Micro- and Nano-diamonds and Nano-onions as Contrast Agents for Breast Cancer.
A Phantom Study of Terahertz Spectroscopy and Imaging of Micro- and Nano-diamonds and Nano-onions as Contrast Agents for Breast Cancer.
复制标题
DOI：
10.1088/2057-1976/aa87c2
复制
发表时间：
2017-10
影响因子：
1.4
通讯作者：
El-Shenawee M
中科院分区：
文献类型：
--
作者：
Bowman T;Walter A;Shenderova O;Nunn N;McGuire G;El-Shenawee M
太赫兹成像在区分乳腺肿瘤中的癌变组织、健康组织和脂肪组织方面是有效的，但在癌变组织和纤维腺（健康）组织之间的对比仍然是一个挑战。这项工作研究了碳基纳米颗粒作为乳腺癌太赫兹成像的潜在造影剂。在聚二甲基硅氧烷或聚乙烯的低吸收背景下，用太赫兹透射光谱对微金刚石、纳米金刚石和纳米级洋葱状碳进行了表征。根据测量的电场计算折射率和吸收系数。纳米金刚石对太赫兹信号几乎没有影响，微金刚石表现出类似共振的、与尺寸相关的吸收峰，而洋葱状碳即使在低浓度下也能均匀地提高光学性能。由于其与太赫兹频率的强相互作用以及被激活以选择性结合癌细胞的能力，洋葱样碳被应用于工程化的三维乳房肿瘤模型中，该模型由模拟浸润性导管癌的幻像组织和模拟健康纤维腺组织的幻像组织组成。该模型使用太赫兹反射模式成像，以检查对比剂区分两种组织类型的有效性。在光谱学和成像中，10%浓度的洋葱状碳对太赫兹信号的影响最大，有望成为太赫兹造影剂。
THz imaging is effective in distinguishing between cancerous, healthy, and fatty tissues in breast tumors, but a challenge remains in the contrast between cancerous and fibroglandular (healthy) tissues. This work investigates carbon-based nanoparticles as potential contrast agents for terahertz imaging of breast cancer. Microdiamonds, nanodiamonds, and nanometer-scale onion-like carbon are characterized with terahertz transmission spectroscopy in low-absorption backgrounds of polydimethylsiloxane or polyethylene. The refractive index and absorption coefficients are calculated based on the measured electric fields. Nanodiamonds show little effect on the terahertz signal, microdiamonds express resonance-like, size-dependent absorption peaks, and onion-like carbon provides a uniform increase in the optical properties even at low concentration. Due to its strong interaction with terahertz frequencies and ability to be activated for selective binding to cancer cells, onion-like carbon is implemented into engineered three-dimensional breast tumor models composed of phantom tissue mimicking infiltrating ductal carcinoma surrounded by a phantom mimicking healthy fibroglandular tissue. This model is imaged using the terahertz reflection mode to examine the effectiveness of contrast agents for differentiation between the two tissue types. In both spectroscopy and imaging, a 10% concentration of onion-like carbon shows the strongest impact on the terahertz signal and holds promise as a terahertz contrast agent.