Association of metabolite concentrations and water diffusivity in normal appearing brain tissue with glioma grade.
Association of metabolite concentrations and water diffusivity in normal appearing brain tissue with glioma grade.
复制标题
代谢物浓度和胶质瘤级正常出现的脑组织中的水扩散率的关联。
DOI：
10.1111/jon.12063
复制
发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Spielman DM
中科院分区：
文献类型：
--
作者：
Maudsley AA;Roy B;Gupta RK;Sheriff S;Awasthi R;Gu M;Husain N;Mohakud S;Behari S;Spielman DM
脑肿瘤的研究已经在MRI正常出现的组织区域中确定了改变的组织代谢和水扩散。在这项回顾性研究中，这些影像学指标与胶质瘤的肿瘤分级的关系进行了调查。在未经治疗的胶质瘤受试者和正常对照受试者中获得全脑的MR光谱成像和平均扩散率（MD）测量值。在肿瘤位置对侧半球的灰质和白质区域获得N-乙酰天冬氨酸（NAA）、总肌酸（Cre）和总胆碱（Cho）的平均代谢物值，并从对侧正常外观的白色物质获得MD值。分析检验了受试者组之间的平均值差异，同时考虑了年龄。分析表明，增加NAA/Cre和MD，降低Cho/NAA的所有肿瘤等级相对于对照值。肿瘤分级之间的差异也观察到NAA，NAA/Cre，和Cho/NAA。还观察到水扩散的异常值，但扩散变化与组织代谢物之间仅存在弱相关性。这项研究支持了以前观察到的正常白色物质中组织代谢和水扩散的改变，同时还发现了灰质中代谢物值的差异以及与肿瘤分级的相关性。
Studies of brain tumors have identified altered tissue metabolism and water diffusion in MRI normal appearing tissue regions. In this retrospective study the relationship of these imaging measures with tumor grade in gliomas was investigated. MR spectroscopic imaging of whole brain and mean diffusivity (MD) measurements were obtained in subjects with untreated glioma and from normal control subjects. Mean metabolite values for N-acetylaspartate (NAA), total creatine (Cre) and total choline (Cho) were obtained in grey- and white-matter regions for the hemisphere contralateral to the tumor location, and MD values were obtained from contralateral normal-appearing white matter. Analyses tested for differences in mean values between subject groups while accounting for age. Analysis demonstrated increased NAA/Cre and MD, and decreased Cho/NAA for all tumor grades relative to control values. Differences between tumor grades were also observed for NAA, NAA/Cre, and Cho/NAA. Abnormal values of water diffusion were also observed, but with only a weak association between alterations in diffusion and tissue metabolites. This study supports previous observations of altered tissue metabolism and water diffusion in normal-appearing white matter while additionally finding differences of metabolite values in grey-matter and an association with tumor grade.