Heparin, heparan sulfate and heparanase in inflammatory reactions
Heparin, heparan sulfate and heparanase in inflammatory reactions
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DOI：
10.1160/th09-02-0091
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发表时间：
2009-11-01
影响因子：
6.7
通讯作者：
Vlodavsky, Israel
中科院分区：
文献类型：
--
作者：
Li, Jin-ping;Vlodavsky, Israel
大多数动物组织的细胞表面和细胞外基质中的硫酸乙酰肝素（HS）蛋白聚糖在发育和稳态中是必不可少的，并且与疾病过程有关。新出现的证据表明，HS在炎症反应中的重要作用，特别是在调节白细胞外渗。肝素是一种经典的抗凝剂，在动物模型和临床中表现出抗炎作用，可能是通过干扰HS的功能，因为两种多糖在分子结构上具有高度相似性。除了生物合成过程中的调节外，HS和肝素的结构还受到乙酰肝素酶的显著调节，乙酰肝素酶是一种在许多炎性疾病中上调的内切糖苷酶。探讨HS和肝素的生理作用以及乙酰肝素酶在炎症反应中调节其功能的作用方式对未来的研究具有重要意义。
Heparan sulfate (HS) proteoglycans at the cell surface and in the extracellular matrix of most animal tissues are essential in development and homeostasis, and are implicated in disease processes. Emerging evidence demonstrates the important roles of HS in inflammatory reactions, particularly in the regulation of leukocyte extravasation. Heparin, a classical anticoagulant, exhibits anti-inflammatory effects in animal models and in the clinic, presumably through interference with the functions of HS, as both polysaccharides share a high similarity in molecular structure. Apart of regulation during biosynthesis, the structures of HS and heparin are significantly modulated by heparanase, an endoglycosidase that is upregulated in a number of inflammatory conditions. Exploring the physiological roles of HS and heparin and the mode of heparanase action in modulating their functions during inflammation responses is of importance for future studies.