Microaerosol and Nanoparticle Synthesis for Drug Delivery via Surface Acoustic Wave Atomization
Microaerosol and Nanoparticle Synthesis for Drug Delivery via Surface Acoustic Wave Atomization
复制标题
通过表面声波雾化进行药物输送的微气溶胶和纳米颗粒合成
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
D. R. Arifin
中科院分区：
文献类型：
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作者：
M. Alvarez;J. Friend;L. Yeo;D. R. Arifin
We describe the fabrication of a surface acoustic wave (SAW) atomizer, and show its ability to generate monodisperse aerosol and particles for drug delivery applications. In particular, we demonstrate the generation of insulin microdroplets for pulmonary delivery, and polymeric nanoparticles for one-step rapid encapsulation using SAW devices with resonance frequencies of 8.6 MHz and 19.3 MHz. Insulin droplets around 4 μm were obtained, matching the optimum range for maximising droplet absorption in the alveolar region. Nanoscale polymer particles (130- 220 nm in diameter) were obtained through a non-equilbrium evaporation and nucleation process, thereby presenting a quick and simple means for nanoparticle synthesis. These results exhibit the feasibility of SAW as a novel method for producing particles and droplets of controlled sizes.
