Effect of nitroprusside on hydraulic vascular loads on the right and left ventricle of patients with heart failure.
Effect of nitroprusside on hydraulic vascular loads on the right and left ventricle of patients with heart failure.
复制标题
硝普钠对心力衰竭患者左右心室水压血管负荷的影响。
DOI：
10.1161/01.cir.67.6.1330
复制
发表时间：
1983
期刊：
影响因子：
37.8
通讯作者：
Weisfeldt,ML
中科院分区：
文献类型：
--
作者：
Yin,FC;Guzman,PA;Brin,KP;Maughan,WL;Brinker,JA;Traill,TA;Weiss,JL;Weisfeldt,ML
本文观察了硝普钠对7例严重左心衰患者左、右心室水力血管负荷的影响。在0.25-0.75微克/千克/分钟的剂量下，每搏输出量从40.1毫升逐渐增加到48.6毫升，左心室舒张末期压从24.5毫米汞柱降低到11.2毫米汞柱。伴随着左心室性能的改善，平均心室压、肺动脉和全身阻力以及输入阻抗模量的低频分量呈剂量相关性降低。特征阻抗和总的和振荡的外部功率下降，肺动脉，但不是主动脉，脉管系统。在这类患者中，右心室去负荷是硝普钠的显著和直接的作用，并可能通过心室相互依赖性部分地改善左心室性能。
We studied the effect of nitroprusside on the hydraulic vascular load of the right and left ventricle in seven patients with severe left ventricular failure. At doses of 0.25-0.75 micrograms/kg/min, stroke volume increased progressively from 40.1 to 48.6 ml and left ventricular end-diastolic pressure decreased from 24.5 to 11.2 mm Hg. Accompanying this improvement in left ventricular performance were dose-related decreases in mean ventricular pressures, pulmonic and systemic resistances and the lower-frequency components of input impedance moduli. Characteristic impedance and both total and oscillatory external power were decreased in the pulmonic, but not the aortic, vasculature. In this class of patients, right ventricular unloading is a striking and direct effect of nitroprusside and may account, in part, for improved left ventricular performance through ventricular interdependence.