Overview of microRNA biology.
Overview of microRNA biology.
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DOI：
10.1055/s-0034-1397344
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发表时间：
2015-02
影响因子：
4.2
通讯作者：
Mott JL
中科院分区：
文献类型：
--
作者：
Mohr AM;Mott JL
在概述 microRNA 生物学时，将 microRNA 视为细胞通讯的一部分是有用的。在最简单的水平上，microRNA 的作用是降低含有与 microRNA 互补的序列片段的 mRNA 的表达。该功能可以比作内源性或合成的短干扰RNA (siRNA) 的功能。然而，microRNA 的功能比这种“开关”模型所暗示的更为复杂和微妙。此外，许多 microRNA 靶标本身就是非编码 RNA。在这篇综述中，我们将讨论 microRNA 在塑造细胞蛋白质组中的作用，其方式与 microRNA 参与高度调控的对话一致，对外部影响和内部反馈敏感。
In considering an overview of microRNA biology, it is useful to consider microRNAs as a part of cellular communication. At the simplest level, microRNAs act to decrease the expression of mRNAs that contain stretches of sequence complementary to the microRNA. This function can be likened to the function of endogenous or synthetic short interfering RNA (siRNA). However, microRNA function is more complicated and nuanced than this ‘on-off’ model would suggest. Further, many microRNA targets are themselves non-coding RNAs. In this review, we will discuss the role of microRNAs in shaping the proteome of the cell in a way that is consistent with microRNA involvement in a highly regulated conversation, sensitive to outside influence and internal feedback.