Drop in Platelet Counts in Extremely Preterm Neonates and Its Association With Clinical Outcomes
Drop in Platelet Counts in Extremely Preterm Neonates and Its Association With Clinical Outcomes
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DOI：
10.1097/mph.0b013e31821e5f44
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发表时间：
2011-12-01
影响因子：
1.2
通讯作者：
Rastogi, Deepa
中科院分区：
文献类型：
--
作者：
Rastogi, Shantanu;Olmez, Inan;Rastogi, Deepa
背景：血小板减少症是早产儿常见的疾病，与死亡率和发病率相关。在最近的成人研究中，血小板数量的下降已被证明是临床结果的预测因素。尽管在新生儿中也观察到血小板计数下降伴或不伴血小板减少症，但其与早产儿死亡率和发病率的关系尚未在早产儿人群中进行研究。Objective：To study a >= 30% drop in platelet counts in preterm neurons and its association with clinical outcome.Methods：Retrospective chart review was done on neurons born at gestational age = 7 days.与成人研究一样，在7天和28天时确定了血小板数量下降>= 30%，并研究了其与死亡率、发病率和住院时间（LOS）的关系。286例患者的平均胎龄为26.3周（范围：23 - 28周），出生体重为899 +/- 215 g。68.1%的新生儿血小板计数下降≥ 30%。与死亡率显著相关（P
Background: Thrombocytopenia is a common finding among preterm neonates and has been associated with mortality and morbidities. In recent studies in adults, the drop in platelet numbers has been shown to be a predictor of clinical outcomes. Although drop in the platelet counts with or without thrombocytopenia has also been observed in neonates, its association with mortality and morbidity has not been investigated in the preterm population.Objective: To study the prevalence of a >= 30% drop in platelet counts in preterm neonates and its association with clinical outcomes.Methods: Retrospective chart review was done on neonates born at gestational age = 7 days. As with the adult studies, a >= 30% drop in platelet numbers were identified at 7 days and 28 days of age and their association with mortality, morbidities, and length of stay (LOS) was investigated.Results: Two hundred eighty-six patients included in the study had a mean gestational age of 26.3 weeks (range, 23 to 28 wk) and birth weight of 899 +/- 215 grams. A >= 30% drop in platelet counts occurred in 68.1% neonates. It was significantly associated with mortality (P