MicroRNAs in ovarian carcinomas.
MicroRNAs in ovarian carcinomas.
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DOI：
10.1677/erc-09-0203
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发表时间：
2010-03
影响因子：
3.9
通讯作者：
Morin PJ
中科院分区：
文献类型：
--
作者：
Dahiya N;Morin PJ
上皮性卵巢癌发生和发展的分子机制才刚刚开始阐明。特别是，microRNAs(MiRNAs)，一类转录后调节基因表达的分子，在卵巢肿瘤的发生中发挥着重要作用。几项miRNA图谱研究已经确定了在卵巢癌发展过程中发生的miRNA模式的变化。虽然大多数失控的miRNAs在癌症中表达下调，因此可能起到肿瘤抑制作用，但其他miRNAs表达上调，可能代表了这种疾病中的新癌基因。许多在卵巢癌中异常表达的miRNAs已被证明在癌症的发展中具有重要的功能作用，因此可能是治疗的靶点。此外，一些miRNA模式可能具有预后意义。识别功能靶点是我们理解miRNA在卵巢癌中功能的主要障碍，但正在取得重大进展。希望更好地了解miRNA在卵巢癌中的表达和作用，可能为这一致命疾病的检测、诊断和治疗提供新的途径。
The molecular mechanisms involved in epithelial ovarian cancer initiation and progression are just beginning to be elucidated. In particular, it has become evident that microRNAs (miRNAs), a class of molecules that post-trancriptionally regulates gene expression, play a major role in ovarian tumorigenesis. Several miRNA profiling studies have identified changes in miRNA patterns that take place during ovarian cancer development. While most deregulated miRNAs are down-regulated in cancer, and may therefore act as tumor suppressors, others are elevated and may represent novel oncogenes in this disease. A number of miRNAs identified as aberrantly expressed in ovarian carcinoma have been shown to have important functional roles in cancer development and may therefore represent targets for therapy. In addition, some of the miRNA patterns may have prognostic significance. The identification of functional targets represents a major hurdle in our understanding of miRNA function in ovarian carcinoma, but significant progress is being made. It is hoped that a better understanding of the miRNA expression and roles in ovarian cancer may provide new avenues for the detection, diagnosis, and therapy of this deadly disease.