Iron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents
Iron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents
复制标题
使用格氏试剂的铁催化烯醇甲苯磺酸酯的立体特异性芳基化
DOI：
10.1039/c9cc09522e
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Duan Xin-Fang
中科院分区：
文献类型：
--
作者：
Wei Yi-Ming;Ma Xiao-Di;Wang Lei;Duan Xin-Fang
报道了铁催化烯醇对甲苯磺酸酯的立体定向芳基化反应。用普通格氏试剂和Knochel型格氏试剂对β-酮酯的各种三取代或四取代的Z或E-烯醇甲苯磺酸酯进行了完全立体忠实性的芳基化。Z/E-zimelidine，他莫昔芬和其他生物活性化合物的前体容易地制备，而不需要昂贵和有毒的过渡金属。
The stereospecific Fe-catalyzed arylation of enol tosylates was reported. Various tri- or tetrasubstituted Z or E-enol tosylates of β-keto esters were arylated using common and Knochel-type Grignard reagents with complete stereofidelity. The precursors for Z/E-zimelidine, tamoxifen and other bioactive compounds were facilely prepared without precious and toxic transition metals.