The prevalence of multimorbidity and associations with lifestyle factors among middle-aged Canadians: an analysis of Canadian Longitudinal Study on Aging data
The prevalence of multimorbidity and associations with lifestyle factors among middle-aged Canadians: an analysis of Canadian Longitudinal Study on Aging data
复制标题
DOI：
10.1186/s12889-019-6567-x
复制
发表时间：
2019-02-28
影响因子：
4.5
通讯作者：
Menec, Verena
中科院分区：
文献类型：
--
作者：
Sakib, Mohammad Nazmus;Shooshtari, Shahin;Menec, Verena
背景：多重发病可以定义为一个人存在不止一种慢性病。对多重病的研究主要集中在老年人身上，很少有研究考察中年人的多重病。本研究的目的是：1）调查加拿大中年人中多种疾病的患病率； 2) 检查该年龄组的生活方式因素（吸烟、饮酒、体力活动）与多种疾病之间的关联。方法：在对加拿大老龄化纵向研究 (CLSA) 基线数据的分析中，我们从包含 51,338 名 45-85 岁人群的数据库中提取了 29,841 名 45-64 岁参与者的数据。使用 27 种慢性身体健康状况的自我报告数据得出不同的多发病定义。出于描述目的，我们估计了不同亚组中 3+ 至 5+ 种慢性身体健康状况的患病率。进行多变量逻辑回归分析，以确定社会人口统计学和生活方式因素以及使用 3+ 多重发病病例定义的多重发病之间的关联。结果：我们发现 39.6% (99% CI 38.4-40.7) 的参与者患有三种或更多慢性病，平均慢性病数量为 2.41 (99% CI 2.37-2.46)。多种疾病的患病率随着年龄的增长而增加，从 45-49 岁年龄组的 29.7% 增加到 60-64 岁人群的 52%。 4+和5+慢性病的患病率分别为24.5%和14.2%。分析表明，女性和低收入与较高的多重发病率相关，而每日或每周饮酒量与较低的多重发病率相关。运动与多种疾病无关。分别对女性和男性进行分析时，结果相似。结论：多重发病不仅限于老年人，而且是中年人中的普遍现象。需要进行纵向研究以更好地了解生活方式因素与多发病之间的时间关系。
Background: Multimorbidity can be defined as the presence of more than one chronic condition in an individual. Research on multimorbidity has predominantly focused on older adults and few studies have examined multimorbidity in middle-aged people. The objectives of this study were to: 1) examine the prevalence of multimorbidity among middle-aged Canadians; and 2) examine the association between lifestyle factors (smoking, alcohol intake, physical activity) and multimorbidity in this age group.Methods: In this analysis of the Canadian Longitudinal Study on Aging (CLSA) baseline data, we extracted data from 29,841 participants aged 45-64 years from a database of 51,338 people aged 45-85 years. Self-reported data on 27 chronic physical health conditions were used to derive different multimorbidity definitions. We estimated the prevalence of 3+ to 5+ chronic physical health conditions in different subgroups for descriptive purposes. Multivariable logistic regression analyses were performed to determine the association between socio-demographic and lifestyle factors, and multimorbidity using a 3+ multimorbidity case definition.Result: We found that 39.6% (99% CI 38.4-40.7) of participants had three or more chronic conditions with a mean number of chronic condition of 2.41 (99% CI 2.37-2.46). The prevalence of multimorbidity increased with age from 29.7% in the 45-49-year-old age group to 52% in individuals aged 60-64 years. The prevalence of 4+ and 5+ chronic conditions was 24.5 and 14.2% respectively. Analyses indicated that female sex and low income were associated with higher odds of multimorbidity, whereas daily or weekly alcohol intake were associated with lower odds of multimorbidity. Exercise was not associated with multimorbidity. Results were similar when analyses were conducted separately for women and men.Conclusions: Multimorbidity is not limited to older adults, but is a common phenomenon among middle-aged people. Longitudinal research is needed to better understand the temporal relationship between lifestyle factors and multimorbidity.