THE EPIDEMIOLOGY OF SERUM SEX-HORMONES IN POSTMENOPAUSAL WOMEN
THE EPIDEMIOLOGY OF SERUM SEX-HORMONES IN POSTMENOPAUSAL WOMEN
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DOI：
10.1093/oxfordjournals.aje.a115234
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发表时间：
1989-06-01
影响因子：
5
通讯作者：
POWELL, JG
中科院分区：
文献类型：
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作者：
CAULEY, JA;GUTAI, JP;POWELL, JG
血清性激素可能与绝经后妇女患多种疾病的风险有关。在本报告中，作者检查了从美国宾夕法尼亚州匹兹堡大都会地区招募的 176 名健康白人绝经后女性（平均年龄 58 岁）的血清性激素流行病学。数据收集于 1982 年至 1983 年期间；所有女性均未接受雌激素替代疗法。通过提取、柱色谱和放射免疫分析的组合来测量雌酮、雌二醇、睾酮和雄烯二酮的血清浓度。年龄和绝经后的时间都不是性激素的重要预测因素。肥胖程度是雌酮和雌二醇的主要决定因素。肥胖女性的雌酮水平比非肥胖女性高约 40%。肥胖与雄激素之间的关系较弱。吸烟者的雄烯二酮水平显着高于不吸烟者，而吸烟者和不吸烟者之间的血清雌激素差异不大。雌酮和雌二醇水平都随着饮酒量的增加而下降。体力活动是血清雌酮的独立预测因子。越活跃的女性雌酮水平越低。肌肉力量与雌激素水平呈正相关。这些数据表明环境和生活方式因素与血清性激素之间存在有趣的关系。这些环境和生活方式因素可能是可以改变的，因此，如果性激素和疾病之间存在关联，这些因素的改变可能会影响疾病风险。
Serum sex hormones may be related to the risk of several diseases in postmenopausal women. In the current report, the authors examined the epidemiology of serum sex hormones in 176 healthy, white postmenopausal women (mean age 58 years) recruited from the metropolitan Pittsburgh, Pennsylvania (USA), area. The data were collected during 1982-1983; none of the women were on estrogen replacement therapy. Serum concentrations of estrone, estradiol, testosterone, and androstenedione were measured by a combination of extraction, column chromatography, and radioimmunoassay. Neither age nor time since menopause was a significant predictor of sex hormones. The degree of obesity was a major determinant of estrone and estradiol. The estrone levels of obese women were about 40% higher than the levels of nonobese women. There was a weak relation between obesity and the androgens. Cigarette smokers has significantly higher levels of androstenedione than nonsmokers, with little difference in serum estrogens between smokers and nonsmokers. Both estrone and estradiol levels tended to decline with increasing alcohol consumption. Physical activity was an independent predictor of serum estrone. More active women had lower levels of estrone. There was a positive relation of muscle strength with estrogen levels. The data suggest interesting relations between environmental and lifestyle factors and serum sex hormones. These environmental and lifestyle factors are potentially modifiable and, hence, if associations between sex hormones and disease exist, modification of these factors could affect disease risks.