Test-Retest Reliability of Effective Connectivity in the Face Perception Network
Test-Retest Reliability of Effective Connectivity in the Face Perception Network
复制标题
DOI：
10.1002/hbm.23061
复制
发表时间：
2016-02-01
影响因子：
4.8
通讯作者：
Jansen, Andreas
中科院分区：
文献类型：
--
作者：
Fraessle, Stefan;Paulus, Frieder Michel;Jansen, Andreas
计算方法有很大的潜力，使神经科学朝着大脑区域之间功能整合的机制模型发展。动态因果模型（DCM）提供了一个很有前途的框架，推断大脑区域之间的有效连接，从而揭开正常认知功能和精神疾病的神经机制。虽然此类方法的益处在很大程度上取决于其可靠性，但对受试者内稳定性的系统分析却很少见。在这里，我们提出了一个彻底的调查重测信度的功能磁共振成像模式DCM分析致力于解开内和半球间的整合的核心区域之间的面孔感知网络。首先，我们在25名健康志愿者中研究了面部特异性BOLD活动的可靠性，他们在两个单独的会议中进行了面部感知范式。我们发现，良好的可靠性，以出色的BOLD活动的DCM相关区域内。其次，我们通过分析DCM中贝叶斯模型选择和模型参数估计的可靠性来评估这些区域之间有效连通性的稳定性。可靠性是优秀的负自由能和良好的模型参数估计，当限制分析的参数与实质性的效果大小。第三，即使缩短实验时间，BOLD活性和DCM结果的可靠性也只是随着实验时间的延长而略有下降。这表明，这里提出的人脸感知范式提供了可靠的估计，传统的激活和有效的连接措施。最后，我们展望了潜在的临床应用的范式研究精神疾病。(C)2015 Wiley Periodicals，Inc.
Computational approaches have great potential for moving neuroscience toward mechanistic models of the functional integration among brain regions. Dynamic causal modeling (DCM) offers a promising framework for inferring the effective connectivity among brain regions and thus unraveling the neural mechanisms of both normal cognitive function and psychiatric disorders. While the benefit of such approaches depends heavily on their reliability, systematic analyses of the within-subject stability are rare. Here, we present a thorough investigation of the test-retest reliability of an fMRI paradigm for DCM analysis dedicated to unraveling intra-and interhemispheric integration among the core regions of the face perception network. First, we examined the reliability of face-specific BOLD activity in 25 healthy volunteers, who performed a face perception paradigm in two separate sessions. We found good to excellent reliability of BOLD activity within the DCM-relevant regions. Second, we assessed the stability of effective connectivity among these regions by analyzing the reliability of Bayesian model selection and model parameter estimation in DCM. Reliability was excellent for the negative free energy and good for model parameter estimation, when restricting the analysis to parameters with substantial effect sizes. Third, even when the experiment was shortened, reliability of BOLD activity and DCM results dropped only slightly as a function of the length of the experiment. This suggests that the face perception paradigm presented here provides reliable estimates for both conventional activation and effective connectivity measures. We conclude this paper with an outlook on potential clinical applications of the paradigm for studying psychiatric disorders. (C) 2015 Wiley Periodicals, Inc.