Segmental Volume Changes that Occur in Nonhuman Primates During Short Term Head Up (HUT) and Head Down (HDT) Tilt.
Segmental Volume Changes that Occur in Nonhuman Primates During Short Term Head Up (HUT) and Head Down (HDT) Tilt.
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DOI：
10.2478/joeb-2020-0003
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发表时间：
2020-01
影响因子：
--
通讯作者：
Oloff C
中科院分区：
文献类型：
--
作者：
Montgomery LD;Oloff C
非人类灵长类动物经常用于生物医学研究和研究人类发生的生理过程。使用阻抗体积描记法测量 10 只恒河猴和 8 只松鼠猴在 5、10 和 20 度角度暴露于 HUT 和 HDT 5 分钟期间的小腿、大腿、骨盆、腹部和胸部体积变化。在 HUT 和 HDT 10 度和 20 度下对三只松鼠猴进行小腿、臀部和尾巴测量。研究发现，在 HUT 和 HDT 期间，恒河猴所有节段的液体体积变化与所用的倾斜角度直接相关。然而，松鼠猴身上发生的体积变化却截然不同。在 HUT 和 HDT 过程中，它们的小腿、大腿和骨盆部分体积缩小，而它们的腹部和胸部部分的反应与恒河猴相似。这些结果以及松鼠猴的犊牛/尾巴测量结果表明，它们可能在姿势变化期间利用尾巴作为补偿库，因此在某些直立测试条件下可能不是适合人类的动物模型。
Nonhuman primates are often used in biomedical research and to investigate physiologic processes that occur in man. Impedance plethysmography was used to measure calf, thigh, pelvic, abdominal, and thoracic volume changes in ten Rhesus and eight squirrel monkeys during five-minute exposures to HUT and HDT at angles of 5, 10, and 20 degrees. Calf, rump and tail measurements were made in three squirrel monkeys at 10 and 20 degrees of HUT and HDT. Fluid volume changes in all segments of the Rhesus monkeys were found to change during HUT an HDT in direct relation to the angle of tilt used. However, the volume changes that occurred in the squirrel monkeys were found to be quite different. Their calf, thigh, and pelvic segments lost volume during both HUT and HDT while their abdominal and thoracic segments responded similarly to those of the Rhesus monkeys. These results and those of the calf/tail measurements of the squirrel monkeys suggest that they may utilize their tails as a compensatory reservoir during postural changes and therefore, may not be an appropriate animal model for man under some orthostatic test conditions.