The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population
The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population
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DOI：
10.1016/j.jns.2011.06.036
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发表时间：
2011-09-15
影响因子：
4.4
通讯作者：
Chen, Sheng-Di
中科院分区：
文献类型：
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作者：
Ren, Ru-Jing;Wang, Li-Ling;Chen, Sheng-Di
本研究旨在探讨MTHFD1L基因rs11754661多态性与中国汉族人群阿尔茨海默病（AD）的关系（n=380，年龄>50）以确定MTHFD 1L一种常见单核苷酸多态性（SNP）的患病率（rs11754661）在中国大陆中国人群的AD患者中，并阐明了这种多态性是否是AD的危险因素。AD患者与对照组rs11754661多态性差异有统计学意义（P
Our objective is to evaluate the relationship between the rs11754661 polymorphism of the MTHFD1L gene and Alzheimer's disease (AD) in the ethnic Chinese Han.We conducted a case-control study (n=380, age>50) to determine the prevalence of one common single-nucleotide polymorphism (SNP) of MTHFD1L (rs11754661) in patients with AD in Chinese population of Mainland China, and clarified whether this polymorphism is a risk factor for AD.The prevalence of the minor allele (A) in the rs11754661 polymorphism was significantly different in AD patients and control subjects (P