Prognostic value of FDG uptake in early stage non-small cell lung cancer
Prognostic value of FDG uptake in early stage non-small cell lung cancer
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DOI：
10.1016/j.ejcts.2008.02.005
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发表时间：
2008-05-01
影响因子：
3.4
通讯作者：
Poncelet, Alain J.
中科院分区：
文献类型：
--
作者：
Hanin, Francois-Xavier;Lonneux, Max;Poncelet, Alain J.
背景：非小细胞肺癌（NSCLC）即使在疾病的早期阶段（I期和II期）预后也很差。我们研究了PET FDG在完全切除的I期和II期NSCLC患者中的预后价值。方法：回顾性分析96例NSCLC患者的F-18-FDG PET（氟脱氧葡萄糖正电子发射断层扫描）分期。Hierarchotogicat分期为I期（75例）或II期（n = 21例）。FDG摄取被测量为最大值。体重标准化摄取值（SUVmax）。平均随访45 ~ 30个月（1142个月）。记录总体和无癌生存率。结果：II期的SUVmax高于I期（10.5 +/- 4.5 vs 8.5 +/- 5，p = 0.04）。两个分期的平均肿瘤体积相等（33 cm（3），p = 0.18），不包括部分体积效应。整个研究人群的中位SUVmax为7.8。中位生存期在有塔的患者中显著延长（SUVmax
Background: Non-small cell lung cancer (NSCLC) has a poor prognosis even for early stages of the disease (stage I and II). We studied the prognostic value of PET FDG in patients with completely resected stage I and II NSCLC. Methods: Retrospective study of 96 patients with NSCLC whose staging included F-18-FDG PET (fluoro deoxy glucose positron emission tomography). Histopathotogicat stage was either stage I (75) or stage II (n = 21). FDG uptake was measured as maximal. standardized uptake value for body weight (SUVmax). Mean follow-up was 45 30 months (1 142 months). Overall and cancer-free survival rates were recorded. Results: SUVmax were higher for stage II than for stage I (10.5 +/- 4.5 vs 8.5 +/- 5, p = 0.04). Mean umor volumes were equivalent for both stages (33 cm(3), p = 0.18), excluding a partial volume effect. The median SUVmax in the whole study population was 7.8. The median survival was significantly longer in patients with a tower (SUVmax