White matter plasticity in the corticospinal tract of musicians: A diffusion tensor imaging study
White matter plasticity in the corticospinal tract of musicians: A diffusion tensor imaging study
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DOI：
10.1016/j.neuroimage.2009.02.025
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发表时间：
2009-07-01
期刊：
影响因子：
5.7
通讯作者：
Jancke, Lutz
中科院分区：
文献类型：
--
作者：
Imfeld, Adrian;Oechslin, Mathias S.;Jancke, Lutz
随着扩散张量成像（DTI）技术的出现，长期实践导致的白质结构塑性变化的研究日益引起人们的关注。专业音乐家为研究白质可塑性提供了理想的模型，因为他们较早开始接受广泛的听觉和感觉运动训练。我们进行了纤维束造影和随后的体素分析，感兴趣区域（ROI）分析。并对26名专业音乐家和13名对照组的皮质脊髓束（CST）扩散参数进行详细的切片分析。所有的分析结果都表明，音乐家组左、右CST的分数各向异性（FA）值显著降低。此外，无论在哪个组，FA的右对称性大于左对称性。在音乐家组中，扩散性与儿童时期开始的音乐训练呈负相关。随后的中位数分成早发和晚发音乐家组（中位数= 7年）显示，与晚发组和对照组相比，早发组的CST弥散性增加。总之，这些基于dti的发现可能表明专业音乐家的CST白质结构发生了可塑性变化。我们的研究结果表明，训练引起的轴突膜扩散特性的改变可能导致径向扩散率的增加，这反映在FA值的降低上。(C) 2009爱思唯尔公司版权所有。
With the advent of diffusion tensor imaging (DTI), the study of plastic changes in white matter architecture due to long-term practice has attracted increasing interest. Professional musicians provide an ideal model for investigating white matter plasticity because of their early onset of extensive auditory and sensorimotor training. We performed fiber tractography and subsequent voxelwise analysis, region of interest (ROI) analysis. and detailed slicewise analysis of diffusion parameters in the corticospinal tract (CST) on 26 professional musicians and a control group of 13 participants. All analyses resulted in significantly lower fractional anisotropy (FA) values in both the left and the right CST in the musician group. Furthermore, a right-greater-than-left asymmetry of FA was observed regardless of group. In the musician group, diffusivity was negatively correlated with the onset of musical training in childhood. A subsequent median split into an early and a late onset musician group (median = 7 years) revealed increased diffusivity in the CST of the early onset group as compared to both the late onset group and the controls. In conclusion, these DTI-based findings might indicate plastic changes in white matter architecture of the CST in professional musicians. Our results imply that training-induced changes in diffusion characteristics of the axonal membrane may lead to increased radial diffusivity as reflected in decreased FA values. (C) 2009 Elsevier Inc. All rights reserved.