Synthesis of a Tumor-Associated2,3-Sialyl-T Glycododecapeptide Antigen from the Tandem Repeat Regionof the Mucin MUC1
Synthesis of a Tumor-Associated2,3-Sialyl-T Glycododecapeptide Antigen from the Tandem Repeat Regionof the Mucin MUC1
复制标题
从粘蛋白 MUC1 的串联重复区域合成肿瘤相关 2,3-Sialyl-T 糖十二肽抗原
作者：
S. Dziadek;H. Kunz
作为开发选择性抗肿瘤疫苗的细胞表面抗原，从上皮muc1中合成了一个肿瘤相关的糖十二肽，携带2,3 -唾液酰t抗原。2,3 - st构建块由T - n -苏氨酸偶联物通过糖链逐步延伸组装而成，并用于在氟不稳定的PTMSEL连接体上合成固相糖肽。
As a cell surface antigen for the development of selective antitumorvaccines, a tumor-associated glycododecapeptide from epithelialMUC1 carrying the 2, 3-sialyl-T antigen was synthesized. The 2, 3-STbuilding block was assembled from a T N-threonine conjugateby stepwise saccharide chain extension and utilized for the solid-phaseglycopeptide synthesis on the fluoride-labile PTMSEL linker.