Positron emission tomography compartmental models: A basis pursuit strategy for kinetic modeling
Positron emission tomography compartmental models: A basis pursuit strategy for kinetic modeling
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DOI：
10.1097/01.wcb.0000045042.03034.42
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发表时间：
2002-12-01
影响因子：
6.3
通讯作者：
Cunningham, TJ
中科院分区：
文献类型：
--
作者：
Gunn, RN;Gunn, SR;Cunningham, TJ
动态正电子发射断层扫描（PET）在体内示踪剂研究的定量动力学建模方法。该方法是基于示踪剂在体内的命运的一般房室描述，并确定与测量数据一致的简约模型。该技术涉及到使用基追踪去噪的方法从过完备字典中确定稀疏选择的动力学基函数。这使得能够表征系统脉冲响应函数，从该系统脉冲响应函数可以估计系统宏观参数的值。这些参数估计可以从感兴趣的区域分析中获得，或者作为来自基于体素的分析的参数图像获得。此外，返回与估计的房室模型中的房室数对应的模型阶次估计值。验证研究评估了两个预先存在的数据为主导的技术，即图形分析和光谱分析的方法的性能。使用[C-11]二丙诺啡（阿片受体）和[C-11]WAY-100635（5-HTIA受体）证明了该技术在测量PET数据中的应用。尽管该方法是在PET神经受体结合研究的背景下提出的，但它普遍适用于神经病学、肿瘤学和心脏病学中PET/SPECT放射性示踪剂研究的量化。
A kinetic modeling approach for the quantification of in vivo tracer studies with dynamic positron emission tomography (PET) is presented. The approach is based on a general compartmental description of the tracer's fate in vivo and determines a parsimonious model consistent with the measured data. The technique involves the determination of a sparse selection of kinetic basis functions from an overcomplete dictionary using the method of basis pursuit denoising. This enables the characterization of the systems impulse response function from which values of the systems macro parameters can be estimated. These parameter estimates can be obtained from a region of interest analysis or as parametric images from a voxel-based analysis. In addition, model order estimates are returned that correspond to the number of compartments in the estimated compartmental model. Validation studies evaluate the methods performance against two preexisting data led techniques, namely, graphical analysis and spectral analysis. Application of this technique to measured PET data is demonstrated using [C-11]diprenorphine (opiate receptor) and [C-11]WAY-100635 (5-HTIA receptor). Although the method is presented in the context of PET neuroreceptor binding studies, it has general applicability to the quantification of PET/SPECT radiotracer studies in neurology, oncology, and cardiology.