An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
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DOI：
10.1086/302061
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发表时间：
1998-10-01
影响因子：
9.8
通讯作者：
Knowler, WC
中科院分区：
文献类型：
--
作者：
Hanson, RL;Ehm, MG;Knowler, WC
遗传因素影响II型糖尿病的发展，但最常见的糖尿病形式的遗传位点尚未确定。进行基因组扫描，以确定与糖尿病和身体质量指数（BMI）在皮马印第安人，一个美洲土著人口与II型糖尿病的高患病率的基因座。在264个核心家庭包含966个兄弟姐妹，516个常染色体标记与相邻标记之间的中位数距离为6.4厘米的基因型。方差分量法用于检验与年龄调整的糖尿病评分和BMI的联系。在多点分析中，与年龄调整的糖尿病（LOD = 1.7）联系的最强证据是在染色体11 q上，该区域也与BMI（LOD = 3.6）联系最紧密。双变量连锁分析强烈拒绝了零假设没有连锁与任何性状和零假设没有贡献的基因座之间的两个性状的协变。同胞对分析表明，额外的潜在的糖尿病易感基因位点的染色体Iq和7q。
Genetic factors influence the development of type II diabetes mellitus, but genetic loci for the most common forms of diabetes have not been identified. A genomic scan was conducted to identify loci linked to diabetes and body-mass index (BMI) in Pima Indians, a Native American population with a high prevalence of type II diabetes. Among 264 nuclear families containing 966 siblings, 516 autosomal markers with a median distance between adjacent markers of 6.4 cM were genotyped. Variance-components methods were used to test for linkage with an age-adjusted diabetes score and with BMI. In multipoint analyses, the strongest evidence for linkage with age-adjusted diabetes (LOD = 1.7) was on chromosome 11q, in the region that was also linked most strongly with BMI (LOD = 3.6). Bivariate linkage analyses strongly rejected both the null hypothesis of no linkage with either trait and the null hypothesis of no contribution of the locus to the covariation among the two traits. Sib-pair analyses suggest additional potential diabetes-susceptibility loci on chromosomes Iq and 7q.