Twenty-year cardiovascular and all-cause mortality trends and changes in cardiovascular risk factors in Gubbio, Italy: the role of blood pressure changes.
Twenty-year cardiovascular and all-cause mortality trends and changes in cardiovascular risk factors in Gubbio, Italy: the role of blood pressure changes.
复制标题
意大利古比奥二十年心血管和全因死亡率趋势以及心血管危险因素的变化：血压变化的作用。
DOI：
10.1097/hjh.0b013e32831cbb0b
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发表时间：
2009
影响因子：
4.9
通讯作者：
Zanchetti,Alberto
中科院分区：
文献类型：
--
作者：
Menotti,Alessandro;Lanti,Mariapaola;Angeletti,Mario;Botta,Gianfranco;Cirillo,Massimo;Laurenzi,Martino;Mancini,Mario;Panarelli,Walter;Scavizzi,Patrizia;Terradura-Vagnarelli,Oscar;Zanchetti,Alberto
AimsIn一项观察性人口研究，持续了20年，死亡率的趋势和心血管危险因素水平的变化之间的关系examined.Methods和resultsIn镇的古比奥，在意大利中部，人口调查测量心血管危险因素进行了20年的间隔。在初始队列的一个子集（1927名男性和2333名女性）中，收集了20年的死亡率数据。在同一年龄范围（20-79岁）的个体中比较心血管危险因素水平，在初始调查（1927名男性和2333名女性）和最终调查（1761名男性和2055名女性）中进行检查。经性别调整的所有死因死亡率显著下降，男性下降28%，女性下降51%，心血管疾病死亡率男性下降50%，女性下降71%。收缩压、血清胆固醇、静息心率、吸烟习惯、体重指数、血糖水平均下降（后两项仅在女性中）和估计的心血管风险，以及血清高密度脂蛋白胆固醇和治疗和控制的高血压患者的比例的增加。在Gubbio进行的观察性研究可能会促使普通民众和医学界采取行动，促进普遍健康。
AimsIn an observational population study that lasted 20 years, the relationships between mortality trends and changes in cardiovascular risk factor levels were examined.Methods and resultsIn the town of Gubbio, in central Italy, population surveys for measurement of cardiovascular risk factors were performed 20 years apart. In a subset of the initial cohort (1927 men and 2333 women), mortality data were collected for 20 years. Cardiovascular risk factor levels were compared in individuals in the same age range (20–79 years) examined at the initial survey (1927 men and 2333 women) and at the final survey (1761 men and 2055 women). Age-adjusted rates significantly declined, by 28% among men and 51% among women, for all causes of death, and by 50% among men and 71% among women for cardiovascular disease deaths. Declines were observed in the levels of systolic blood pressure, serum cholesterol, resting heart rate, smoking habits, BMI, plasma glucose (the latter two only in women) and the estimated cardiovascular risk, together with increases in serum high-density lipoprotein cholesterol and in the proportion of treated and controlled hypertensive patients.ConclusionAlthough similar but less impressive changes were recorded in Italy at large, the existence of the observational study in Gubbio might have motivated the general population and the medical profession towards actions promoting general health.