Is the sheep a suitable model to study the mechanical alterations of disc degeneration in humans? A probabilistic finite element model study.
Is the sheep a suitable model to study the mechanical alterations of disc degeneration in humans? A probabilistic finite element model study.
复制标题
绵羊是研究人类椎间盘退变机械变化的合适模型吗？
DOI：
10.1016/j.jbiomech.2018.12.042
复制
发表时间：
2019
影响因子：
2.4
通讯作者：
Hendrik
中科院分区：
文献类型：
--
作者：
Bashkuev;Reitmaier;Sandra;Schmidt;Hendrik
椎间盘退变是腰痛的主要原因之一，由于其复杂的多因素性质，使得治疗具有挑战性，因此需要进行广泛的研究。实验动物模型已被证明在提高我们对退行性过程和潜在的有前途的治疗方法的理解方面是有价值的。绵羊是目前椎间盘研究中最常用的大型动物模型。然而，尽管绵羊在研究复杂的生物学和细胞学方面具有重要价值，但目前尚不清楚绵羊是否也适合研究人类椎间盘退变的力学方面。利用该模型，可以描述人和羊脊柱节段的几何形状和材料特性以及椎间盘退变的不同表现。在单纯载荷和复合载荷下，研究了人类和绵羊模型的退行性变化是否引起相同的力学反应，不同的退行性变化导致关节活动范围、椎间盘内压力、韧带和小关节载荷的巨大变化。在人类，但不是在ovinemodel，所有这些结果之间的不同程度的degeneration.This有限元模型研究突出了可能的差异，在椎间盘退变的机械反应humanandovine椎间盘，并指出进一步的，更详细的，调查的必要性。
Intervertebral disc degeneration is one major source of low back pain, which because of its complex multifactorial nature renders the treatment challenging and thus necessitates extensive research. Experimental animal models have proven valuable in improving our understanding of degenerative processes and potentially promising therapies. Currently, the sheep is the most frequently used large animalin vivomodel in intervertebral disc research. However, despite its undoubted value for investigations of the complex biological and cellular aspects, to date, it is unclear whether the sheep is also suited to study the mechanical aspects of disc degeneration inhumans.A parametric finite element (FE) model of the L4–5 spinal motion segment was developed. Using this model, the geometry and the material properties of both thehumanand theovinespinal segment as well as different appearances of disc degeneration can be depicted. Under pure and combined loads, it was investigated whether degenerative changes to both thehumanand theovinemodel equivalent caused the same mechanical response.Different patterns of degeneration resulted in large variations in the ranges of motion, intradiscal pressure, ligament and facet loads. In thehuman, but not in theovinemodel, all these results differed significantly between different degrees of degeneration.This FE model study highlighted possible differences in the mechanical response to disc degeneration betweenhumanandovineintervertebral discs and indicates the necessity of further, more detailed, investigations.
登录
查看更多内容
DOI：
10.2106/00004623-197254030-00005
发表时间：
1972-01-01
影响因子：
5.3
作者：
MARKOLF, KL
通讯作者：
MARKOLF, KL
鹿和羊腰椎的解剖特征：与人类腰椎的比较
DOI：
--
发表时间：
2015
期刊：
影响因子：
--
作者：
Wang Yang;Ting Liu;Liangsong Song;Zhi;Youqiong Li;Laijin Lu
通讯作者：
Laijin Lu
椎间盘尺寸显着影响椎间盘中静脉注射溶质的浓度分布：以葡萄糖胺作为模型溶质的计算研究
影响因子：
2.8
作者：
S. Motaghinasab;A. Shirazi;Mohamad Parnianpour;Jill P. G. Urban
通讯作者：
Jill P. G. Urban
影响因子：
--
作者：
Freburger, Janet K.;Holmes, George M.;Agans, Robert P.;Jackman, Anne M.;Darter, Jane D.;Wallace, Andrea S.;Castel, Liana D.;Kalsbeek, William D.;Carey, Timothy S.
通讯作者：
Carey, Timothy S.
DOI：
--
发表时间：
1971
期刊：
Canadian journal of surgery. Journal canadien de chirurgie
影响因子：
--
作者：
J. Sullivan;H. Farfan;D. Kahn
通讯作者：
D. Kahn