Atypical intraosseous meningioma with growth hormone deficiency and hyperparathyroidism after craniospinal irradiation
Atypical intraosseous meningioma with growth hormone deficiency and hyperparathyroidism after craniospinal irradiation
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颅脊髓照射后伴有生长激素缺乏和甲状旁腺功能亢进的非典型骨内脑膜瘤
DOI：
10.1007/s00381-017-3587-7
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Hirose Yuichi
中科院分区：
文献类型：
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作者：
Nakae Shunsuke;Uchida Hiroki;Takayanagi Takeshi;Hasegawa Mitsuhiro;Hirose Yuichi
编辑先生：脑膜瘤是最常见的放射性脑肿瘤，通常发生在放射治疗后的长潜伏期[1]。急性淋巴细胞白血病（ALL）是儿科患者中常见的癌症类型，ALL患者在临床过程中经常接受颅脑放射治疗。继发性肿瘤已成为ALL患者长期存活者的晚期并发症。本文报告一例非典型骨内脑膜瘤、生长激素缺乏症（GHD）和甲状旁腺腺瘤的病例，均可能由儿童时期的颅脑照射诱发。他在2岁时接受了颅脊髓照射（24戈伊）和全身照射（12戈伊）。他有内分泌疾病史，包括GHD和甲状旁腺功能亢进（HPT）。GHD在13岁时被诊断出来。HPT（Ca，11.1 mg/dL; PTH，134.2 pg/mL），由甲状旁腺肿瘤引起，在29岁时被诊断出来。手术切除肿瘤，组织学诊断为甲状旁腺腺瘤。
Dear Editor: Meningioma is the most common radiation-induced brain tumor and usually occurs following a long latent period after radiotherapy [1]. Acute lymphoblastic leukemia (ALL) is a common type of cancer in pediatric patients, and patients with ALL often undergo cranial radiotherapy during their clinical course. Secondary neoplasms have become issue in long-term survivors of ALL patients as late complications. This letter reports a case of atypical intraosseous meningioma, growth hormone deficiency (GHD), and parathyroid adenoma, which may have all been induced by cranial irradiation during childhood.A 30-year-old man was referred to our department for a skull tumor on magnetic resonance imaging (MRI). He had undergone craniospinal irradiation (24 Gy) and total body irradiation (12 Gy) at 2 years of age. He had a history of endocrine disorders, including GHD and hyperparathyroidism (HPT). GHD was diagnosed at 13 years of age. HPT (Ca, 11.1 mg/dL; PTH, 134.2 pg/mL), caused by a parathyroid tumor, was diagnosed at 29 years of age. The tumor was surgically resected and histologically diagnosed as parathyroid adenoma.