Metabolomics, Lipidomics, and Antipsychotics: A Systematic Review.
Metabolomics, Lipidomics, and Antipsychotics: A Systematic Review.
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DOI：
10.3390/biomedicines11123295
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发表时间：
2023-12-13
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
抗精神病药物是治疗许多精神疾病的重要药物治疗选择。不幸的是，选择抗精神病药物往往是一个反复试验的过程，因为缺乏对个体患者最有效和最耐受性的药物的了解。代谢组学，或生物样本中的小分子研究，是一个越来越多使用的组学平台，有可能识别药物疗效和毒性的生物标志物。本系统综述旨在确定与人类抗精神病药物使用相关的代谢物和代谢组学途径。最终，42项研究被纳入本综述，除3项研究外，其余研究均在血浆或血清等血液来源中进行。研究共评估了14种代谢物类别和12种脂质类别。尽管这些研究在方法和结果上高度不同，但磷脂酰胆碱增加、羧酸减少和酰基肉碱减少在服用抗精神病药物的患者中最一致地被认为是紊乱的。此外，在靶向代谢组学和脂质组学研究中，7种代谢物和3种脂质有可重复的发现。目标研究中最一致的发现是确定了抗精神病药物治疗中天冬氨酸的减少。研究提供给研究参与者的细节深度和研究设计各不相同。例如，在某些情况下，缺乏使用的特定抗精神病药物或伴随药物的细节，样品处理和分析的细节深度差异很大。这里的结论表明，抗精神病药物的代谢组学研究有很大的基础，需要更完整的报告，以便进行客观的综合，如荟萃分析。这将允许验证和临床应用最可靠的发现，推动该领域向前发展。未来的研究应谨慎控制，以利用代谢组学的敏感性，同时限制参与者异质性和不同分析方法可能导致的潜在混杂因素。
Antipsychotics are an important pharmacotherapy option for the treatment of many mental illnesses. Unfortunately, selecting antipsychotics is often a trial-and-error process due to a lack of understanding as to which medications an individual patient will find most effective and best tolerated. Metabolomics, or the study of small molecules in a biosample, is an increasingly used omics platform that has the potential to identify biomarkers for medication efficacy and toxicity. This systematic review was conducted to identify metabolites and metabolomic pathways associated with antipsychotic use in humans. Ultimately, 42 studies were identified for inclusion in this review, with all but three studies being performed in blood sources such as plasma or serum. A total of 14 metabolite classes and 12 lipid classes were assessed across studies. Although the studies were highly heterogeneous in approach and mixed in their findings, increases in phosphatidylcholines, decreases in carboxylic acids, and decreases in acylcarnitines were most consistently noted as perturbed in patients exposed to antipsychotics. Furthermore, for the targeted metabolomic and lipidomic studies, seven metabolites and three lipid species had findings that were replicated. The most consistent finding for targeted studies was an identification of a decrease in aspartate with antipsychotic treatment. Studies varied in depth of detail provided for their study participants and in study design. For example, in some cases, there was a lack of detail on specific antipsychotics used or concomitant medications, and the depth of detail on sample handling and analysis varied widely. The conclusions here demonstrate that there is a large foundation of metabolomic work with antipsychotics that requires more complete reporting so that an objective synthesis such as a meta-analysis can take place. This will then allow for validation and clinical application of the most robust findings to move the field forward. Future studies should be carefully controlled to take advantage of the sensitivity of metabolomics while limiting potential confounders that may result from participant heterogeneity and varied analysis approaches.
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影响因子：
3.7
作者：
Yao JK;Dougherty GG Jr;Reddy RD;Keshavan MS;Montrose DM;Matson WR;McEvoy J;Kaddurah-Daouk R
通讯作者：
Kaddurah-Daouk R
影响因子：
4.1
作者：
Ward KM;Yeoman L;McHugh C;Kraal AZ;Flowers SA;Rothberg AE;Karnovsky A;Das AK;Ellingrod VL;Stringer KA
通讯作者：
Stringer KA
影响因子：
6.8
作者：
He Y;Yu Z;Giegling I;Xie L;Hartmann AM;Prehn C;Adamski J;Kahn R;Li Y;Illig T;Wang-Sattler R;Rujescu D
通讯作者：
Rujescu D
DOI：
10.1016/j.pnpbp.2020.109945
发表时间：
2020-07-13
影响因子：
5.6
作者：
de Almeida, Valeria;Alexandrino, Guilherme L.;Martins-de-Souza, Daniel
通讯作者：
Martins-de-Souza, Daniel
影响因子：
3.3
作者：
Al Awam, Khaled;Haussleiter, Ida Sibylle;Thome, Johannes
通讯作者：
Thome, Johannes