Crystal structure and antitumor activity of some rare earth metal complexes with Schiff base
Crystal structure and antitumor activity of some rare earth metal complexes with Schiff base
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DOI：
10.1016/s0277-5387(00)00562-3
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发表时间：
2000-12
期刊：
影响因子：
2.6
通讯作者：
Zheng-yin Yang;Ru-dong Yang;Fashen Li;Kai-bei Yu
中科院分区：
文献类型：
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作者：
Zheng-yin Yang;Ru-dong Yang;Fashen Li;Kai-bei Yu
通过与异烟肼的缩合反应，制备了1-苯基-3-甲基-5-羟基-4-吡唑基苯酮（PMBP）异烟酰腙（H2L）配体。合成了7种稀土金属与H2L配合物，并通过元素分析、IR、UV、1H NMR和热分析对其进行了表征。配合物的通式为Ln(HL)3·3.5H2O（其中Ln(III)=La、Eu、Gd、Tb、Dy、Ho、Er）。x射线衍射分析表明，铕配合物的配位多面体为三棱体。La和Eu复合物具有抗肿瘤活性，对白血病细胞（L1210）的抑制率分别为87.1%和78.5%。
The ligand 1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone (PMBP) isonicotinoyl hydrazone (H2L) was prepared by condensation of PMBP with isoniazid. Seven complexes of rare earth metals with H2L were synthesized and characterized on the basis of elemental analyses, IR, UV,1H NMR spectra and thermal analyses. The general formula of the complexes is Ln(HL)3·3.5H2O (where Ln(III)=La, Eu, Gd, Tb, Dy, Ho and Er). X-ray diffraction analysis showed that the coordination polyhedron of the Eu complex is a tricapped trigonal prism. The La and Eu complexes possess antitumor activity, and the inhibitory rates for leukemia cells (L1210) are 87.1% and 78.5%, respectively.