Wnt/β-catenin signaling in cancers and targeted therapies.
Wnt/β-catenin signaling in cancers and targeted therapies.
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Wnt/β-catenin信号在癌症和靶向治疗中的作用
DOI：
10.1038/s41392-021-00701-5
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发表时间：
2021-08-30
影响因子：
39.3
通讯作者：
Ye L
中科院分区：
文献类型：
--
作者：
Yu F;Yu C;Li F;Zuo Y;Wang Y;Yao L;Wu C;Wang C;Ye L
Wnt/β-catenin信号传导已广泛涉及人类癌症和动物实验癌症模型。Wnt/β-catenin信号通路的异常激活与癌症的患病率增加、恶性进展的进展、不良预后的发展、甚至癌症相关死亡率的上升密切相关。早期的实验研究已经提出了理论潜力，即有效抑制这种信号传导可能为管理各种类型的癌症提供有希望的治疗选择。迄今为止，针对Wnt/β-catenin信号通路的肿瘤治疗方法已被开发出来，这为临床医生提供了新的机会，为Wnt/β-catenin信号通路异常的肿瘤患者提供了更满意、更精确的治疗方法。然而，目前的事实表明，Wnt/β-catenin信号依赖性靶向治疗的临床转化面临着不可忽视的危机和挑战。因此，在这项研究中，我们系统地回顾了Wnt/β-catenin信号传导在癌症和相对靶向治疗中的最新知识，以更清晰，更准确地了解Wnt/β-catenin靶向治疗癌症的发展阶段和潜在局限性。这项研究的见解将帮助读者更好地了解Wnt/β-catenin信号在癌症中的作用，并提供见解，以认识目前在癌症中靶向这种信号的机会和挑战。
Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression, development of poor prognostics, and even ascendence of the cancer-associated mortality. Early experimental investigations have proposed the theoretical potential that efficient repression of this signaling might provide promising therapeutic choices in managing various types of cancers. Up to date, many therapies targeting Wnt/β-catenin signaling in cancers have been developed, which is assumed to endow clinicians with new opportunities of developing more satisfactory and precise remedies for cancer patients with aberrant Wnt/β-catenin signaling. However, current facts indicate that the clinical translations of Wnt/β-catenin signaling-dependent targeted therapies have faced un-neglectable crises and challenges. Therefore, in this study, we systematically reviewed the most updated knowledge of Wnt/β-catenin signaling in cancers and relatively targeted therapies to generate a clearer and more accurate awareness of both the developmental stage and underlying limitations of Wnt/β-catenin-targeted therapies in cancers. Insights of this study will help readers better understand the roles of Wnt/β-catenin signaling in cancers and provide insights to acknowledge the current opportunities and challenges of targeting this signaling in cancers.
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影响因子：
11.1
作者：
Aripaka, Karthik;Gudey, Shyam Kumar;Landstrom, Marene
通讯作者：
Landstrom, Marene
影响因子：
11.4
作者：
Bauer, A;Chauvet, S;Pradel, J
通讯作者：
Pradel, J
影响因子：
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作者：
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通讯作者：
Behera, Digamber
影响因子：
11.4
作者：
Aberle, H;Bauer, A;Kemler, R
通讯作者：
Kemler, R
影响因子：
7.7
作者：
Abdelmaksoud-Damak, Rania;Miladi-Abdennadher, Imen;Mokdad-Gargouri, Raja
通讯作者：
Mokdad-Gargouri, Raja