Traumatic subarachnoid hemorrhage and QTc prolongation
Traumatic subarachnoid hemorrhage and QTc prolongation
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DOI：
10.1097/00008506-200407000-00003
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发表时间：
2004-07-01
影响因子：
3.7
通讯作者：
Gonzalez, LS
中科院分区：
文献类型：
--
作者：
Collier, BR;Miller, SL;Gonzalez, LS
目的：自发性蛛网膜下腔出血(SAH)可导致25%~90%的患者校正QT间期(QTC)延长，但是否合并创伤性SAH(TSAH)尚不清楚。本研究旨在确定TSAH患者是否存在QT间期延长，并评价QT间期延长与TSAH严重程度的关系。设计：回顾104例TSAH患者的记录。在创伤后第0天、第1天和第3天计算QTc值。颅脑计算机断层扫描(CT)使用先前验证的分级标准对严重程度进行分级。根据CT扫描的严重程度比较QTC间期。设置：宾夕法尼亚州二级创伤中心。患者：合并TSAH的创伤患者。干预：无测量和主要结果：67%的TSAH患者出现QTC延长。PTD0、PTD1和PTD3的平均QT间期分别为470+/-169ms、467+/-72ms和465+/-50ms。随着TSAH严重程度的增加，平均QTc值延长(Pearson‘s r=0.855，P=0.003)。结论：TSAH是后天性QTcs延长的常见原因之一。随着TSAH的加重，QT间期离散度延长。
Objective: Spontaneous subarachnoid hemorrhage (SAH) causes a prolonged corrected QT interval (QTc) in 25% to 90% of patients, but whether this occurs with traumatic SAH (tSAH) is unknown. This investigation was conducted to determine whether QTc prolongation occurs with tSAH and to evaluate QTc prolongation with respect to severity of tSAH.Design: Records of 104 consecutive tSAH patients were reviewed. A QTc was calculated on posttrauma day (PTD) 0, 1, and 3. Cranial computed tomography (CT) scans were graded for severity using a previously validated scale. QTc intervals were compared based on CT scan severity.Setting: Pennsylvania level II trauma center.Patients: Trauma patients with tSAH.Interventions: NoneMeasurements and Main Results: QTc prolongation occurred in 67% of those with tSAH. Mean QTc intervals for PTD0, PTD1, and PTD3 were 470 +/- 169 ms, 467 +/- 72 ms, and 465 +/- 50 ms, respectively. As the severity of the tSAH increased, the average QTc became more prolonged (Pearson's r = 0.855, P = 0.003).Conclusions: tSAH is a common cause of an acquired prolonged QTc syndrome. As the tSAH becomes more severe, the QTc becomes more prolonged.