THE ROLE OF INTERLEUKIN-6 IN MUCOSAL IGA ANTIBODY-RESPONSES IN-VIVO
THE ROLE OF INTERLEUKIN-6 IN MUCOSAL IGA ANTIBODY-RESPONSES IN-VIVO
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DOI：
10.1126/science.8160012
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发表时间：
1994-04-22
期刊：
影响因子：
56.9
通讯作者：
KOPF, M
中科院分区：
文献类型：
--
作者：
RAMSAY, AJ;HUSBAND, AJ;KOPF, M
在编码白细胞介素 - 6（IL - 6）的基因被定向破坏的小鼠中，在黏膜处观察到产生免疫球蛋白A（IgA）的细胞数量大幅减少，并且在使用卵清蛋白或牛痘病毒进行黏膜激发后，记录到局部抗体反应严重不足。用经改造可表达IL - 6的重组牛痘病毒进行鼻内感染后，肺部的IgA反应完全恢复。这些发现表明IL - 6在体内局部IgA抗体反应的发展中起关键作用，并说明了载体导向的细胞因子基因治疗的有效性。
In mice with targeted disruption of the gene that encodes interleukin-6 (IL-6), greatly reduced numbers of immunoglobulin A (IgA)-producing cells were observed at mucosae and grossly deficient local antibody responses were recorded after mucosal challenge with either ovalbumin or vaccinia virus. The IgA response in the lungs was completely restored after intranasal infection with recombinant vaccinia viruses engineered to express IL-6. These findings demonstrate a critical role for IL-6 in vivo in the development of local IgA antibody responses and illustrate the effectiveness of vector-directed cytokine gene therapy.