Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19
Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19
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DOI：
10.1021/acschemneuro.0c00286
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发表时间：
2020-06-17
影响因子：
5
通讯作者：
Sanders, Erin C.
中科院分区：
文献类型：
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作者：
Baig, Abdul Mannan;Sanders, Erin C.
由严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的2019新型冠状病毒病（COVID-19）是一种以肺部症状为主的人畜共患病。然而，最近从脑脊液（CSF）中分离出病毒的报道，加上脑内坏死区的放射学证据，阐明了SARS-CoV-2的神经营养潜力。在COVID-19患者中观察到的急性呼吸衰竭令人担忧，可能是由于SARS-CoV-2对脑干中央呼吸调节中心的影响。可以实施适当的干预措施来预防SARS-CoV-2神经系统侵袭的严重后果，以降低COVID患者的发病率和死亡率19。至关重要的是，科学界要提醒医疗保健专业人员注意可以预示他们在COVID-19中进行的隐性神经功能缺损的证据。
The 2019 novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a zoonotic disease that is dominated by pulmonary symptoms. However, recent reports of isolation of the virus from cerebrospinal fluid (CSF) coupled with radiological evidence of zones of necrosis in the brain, have elucidated the neurotropic potential of SARS-CoV-2. The acute respiratory failure seen in patients with COVID-19 is alarming and could be due to the effects of SARS-CoV-2 on the central respiratory regulatory centers in the brainstem. Appropriate interventions can be implemented to prevent severe outcomes of neurological invasion by SARS-CoV-2 to reduce the morbidity and mortality of patients with COVID19. It is of paramount importance that the scientific community alerts the healthcare professionals of the pieces of evidence that can herald them on the covert neurological deficits in progress in COVID-19.