The relationships between trait anxiety, place recognition memory, and learning strategy
The relationships between trait anxiety, place recognition memory, and learning strategy
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DOI：
10.1016/j.bbr.2010.08.028
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发表时间：
2011-01-20
影响因子：
2.7
通讯作者：
Dohanich, Gary P.
中科院分区：
文献类型：
--
作者：
Hawley, Wayne R.;Grissom, Elin M.;Dohanich, Gary P.
啮齿类动物学会使用由大脑特定区域控制的各种策略来导航迷宫。在学习导航空间环境时使用的策略类型受到包括情绪状态在内的许多因素的调节。暴露于压力源或服用致焦虑剂引起的高度焦虑状态，已被发现使雄性大鼠倾向于使用基于纹状体的刺激反应策略，而不是基于海马体的位置策略。然而，目前还没有研究调查自然焦虑水平或特质焦虑与大鼠在双重解决任务中使用的学习策略类型之间的关系。在当前的实验中，内在焦虑水平是在一个开放的领域测量的，并与两个独立的认知任务的表现进行比较，一个是评估地点识别记忆的y形迷宫任务，另一个是评估学习策略的可见平台水迷宫任务。结果表明，y型迷宫的位置识别记忆与水迷宫的位置学习策略的使用相关。此外，较低的特质焦虑水平与较好的位置识别记忆和偏好使用位置学习策略呈正相关。因此，位置记忆能力和位置策略偏差与雄性大鼠的内在焦虑水平有关。(C) 2010 Elsevier B.V.版权所有
Rodents learn to navigate mazes using various strategies that are governed by specific regions of the brain. The type of strategy used when learning to navigate a spatial environment is moderated by a number of factors including emotional states. Heightened anxiety states, induced by exposure to stressors or administration of anxiogenic agents, have been found to bias male rats toward the use of a striatum-based stimulus-response strategy rather than a hippocampus-based place strategy. However, no study has yet examined the relationship between natural anxiety levels, or trait anxiety, and the type of learning strategy used by rats on a dual-solution task. In the current experiment, levels of inherent anxiety were measured in an open field and compared to performance on two separate cognitive tasks, a Y-maze task that assessed place recognition memory, and a visible platform water maze task that assessed learning strategy. Results indicated that place recognition memory on the Y-maze correlated with the use of place learning strategy on the water maze. Furthermore, lower levels of trait anxiety correlated positively with better place recognition memory and with the preferred use of place learning strategy. Therefore, competency in place memory and bias in place strategy are linked to the levels of inherent anxiety in male rats. (C) 2010 Elsevier B.V. All rights reserved.