APOE and cerebral amyloid angiopathy in the elderly
APOE and cerebral amyloid angiopathy in the elderly
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DOI：
10.1097/00001756-200308060-00027
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发表时间：
2003-08-06
期刊：
影响因子：
1.7
通讯作者：
Wilcock, GK
中科院分区：
文献类型：
--
作者：
Love, S;Nicoll, JAR;Wilcock, GK
超过30%的正常老年人患有脑淀粉样血管病(CAA)。 APOE epsilon4 的存在与阿尔茨海默病 (AD) 和脑出血中 CAA 的患病率和严重程度增加有关。我们检查了 152 名年龄 60-102 岁、无 AD 或脑出血患者大脑中 CAA 与 APOE 基因型的关系。 CAA 的患病率随着年龄的增长而增加 (p = 0.003)。 CAA 与 APOE 基因型无关。 epsilon4 的频率与年龄呈显着负相关 (p = 0.016)。患有 epsilon4 的患者的死亡年龄显着低于未患有 epsilon4 的患者 (p = 0.028)。拥有 epsilon4 本身并不增加 CAA 的风险，但即使在没有 AD 或脑出血的情况下，也可能会导致寿命缩短。
Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD or cerebral haemorrhage. Prevalence of CAA increased with age (p = 0.003). CAA was not associated with APOE genotype. The frequency of epsilon4 showed a significant negative association with age (p = 0.016). Age at death was significantly lower in those with than without epsilon4 (p = 0.028). Possession of epsilon4 does not by itself confer an increased risk of CAA but may be associated with reduced longevity even in the absence of AD or cerebral haemorrhage.