Delayed mismatch field for speech and non-speech sounds in children with autism
Delayed mismatch field for speech and non-speech sounds in children with autism
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DOI：
10.1097/00001756-200504040-00021
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发表时间：
2005-04-04
期刊：
影响因子：
1.7
通讯作者：
Roberts, TPL
中科院分区：
文献类型：
--
作者：
Cardy, JEO;Flagg, EJ;Roberts, TPL
本研究调查了自闭症谱系障碍(ASD)儿童元音或声调音流的变化引起的磁场失配场，以探索声音辨别能力受损是否可能导致自闭症谱系障碍儿童的语言障碍。使用脑磁图，我们记录了300赫兹和700赫兹音调(以及/u/和/a/元音)的诱发神经活动，呈现在一个奇怪的范例中，其中异常刺激(15%)发生在一系列标准(85%)内。在两组中都强烈地观察到了磁场失配，但与典型的发育中的同龄人相比，患有自闭症谱系障碍的儿童表现出显著延迟的磁场失配。在自闭症谱系障碍中，难以分析声音的瞬时差异可能会导致声学或语音表征的损害，并随后导致语言障碍。(C)2005年，Lippincott Williams&Wilkins。
This study investigated the magnetic mismatch field elicited by changes in streams of vowels or spectrally matched tones in children with autism spectrum disorder (ASD) relative to children with typical development to explore whether impaired sound discrimination may contribute to language impairments in autism spectrum disorder. Using magnetoencephalography, we recorded evoked neural activity to 300-Hz and 700-Hz tones (and /u/ and /a/ vowels) presented in an oddball paradigm with deviant stimuli (15%) occurring within a train of standards (85%). The magnetic mismatch field was robustly observed in both groups, but children with autism spectrum disorder demonstrated a significantly delayed magnetic mismatch field compared with typically developing peers. Difficulty parsing transient differences in sounds may lead to impaired acoustic or phonological representations and subsequent language impairment in autism spectrum disorder. (c) 2005 Lippincott Williams & Wilkins.