ELECTRICAL INJURY MECHANISMS - ELECTRICAL BREAKDOWN OF CELL-MEMBRANES
ELECTRICAL INJURY MECHANISMS - ELECTRICAL BREAKDOWN OF CELL-MEMBRANES
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DOI：
10.1097/00006534-198711000-00002
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发表时间：
1987-11-01
影响因子：
3.6
通讯作者：
KOLODNEY, MS
中科院分区：
文献类型：
--
作者：
LEE, RC;KOLODNEY, MS
电场能够通过热和非热机制损坏细胞。虽然焦耳热被普遍认为可以介导电创伤中的组织损伤，但细胞膜电击穿的可能作用尚未得到充分考虑。有证据表明，在许多电损伤的情况下，局部电场的强度足以引起细胞膜的电击穿和细胞裂解。理论上，肌肉和神经细胞等大细胞更容易受到电击穿。为了说明细胞大小和方向的重要性，分析了细长细胞的几何简单模型。
Electric fields are capable of damaging cells through both thermal and nonthermal mechanisms. While joule heating is generally recognized to mediate tissue injury in electrical trauma, the possible role of electrical breakdown of cell membranes has not been thoroughly considered. Evidence is presented suggestive that in many instances of electrical trauma the local electric field is of sufficient magnitude to cause electrical breakdown of cell membranes and cell lysis. In theory, large cells such as muscle and nerve cells are more vulnerable to electrical breakdown. To illustrate the significance of cell size and orientation, a geometrically simple model of an elongated cell is analyzed.