COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.
COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.
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Covid-19和感染后的肌动脑膜炎/慢性疲劳综合征：叙事评论。
DOI：
10.1177/20499361211009385
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发表时间：
2021-01
影响因子：
5.7
通讯作者：
Cowan J
中科院分区：
文献类型：
--
作者：
Poenaru S;Abdallah SJ;Corrales-Medina V;Cowan J
2019年冠状病毒病（COVID-19）是一种病毒感染，可引起多种呼吸道、胃肠道和血管症状。急性期一般不超过2-3周。然而，越来越多的证据表明，一部分COVID-19患者经历了长时间的康复期，并在首次感染后持续数月出现症状。已报告了多种慢性症状，包括疲劳、呼吸困难、肌痛、运动不耐受、睡眠障碍、注意力难以集中、焦虑、发热、头痛、不适和眩晕。这些症状与肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）中观察到的症状相似，ME/CFS是一种慢性多系统疾病，其特征为严重疲劳、睡眠障碍、神经认知变化、直立不耐受和运动后不适。ME/CFS症状会因运动或压力而加重，并且在没有任何显著的临床或实验室检查结果的情况下发生。ME/CFS的病理学尚不清楚：它被认为是多因素的，由多个系统对特定触发因素的反应失调引起。虽然不完全被认为是感染后实体，但ME/CFS与几种感染因子相关，包括EB病毒，Q热，流感和其他冠状病毒。急性COVID-19后症状与ME/CFS之间存在重要的相似性。然而，目前没有足够的证据确定COVID-19是ME/CFS的传染性触发因素。需要进一步的研究来确定这种情况的自然史，以及确定危险因素，患病率和可能的干预策略。
Coronavirus disease 2019 (COVID-19) is a viral infection which can cause a variety of respiratory, gastrointestinal, and vascular symptoms. The acute illness phase generally lasts no more than 2–3 weeks. However, there is increasing evidence that a proportion of COVID-19 patients experience a prolonged convalescence and continue to have symptoms lasting several months after the initial infection. A variety of chronic symptoms have been reported including fatigue, dyspnea, myalgia, exercise intolerance, sleep disturbances, difficulty concentrating, anxiety, fever, headache, malaise, and vertigo. These symptoms are similar to those seen in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a chronic multi-system illness characterized by profound fatigue, sleep disturbances, neurocognitive changes, orthostatic intolerance, and post-exertional malaise. ME/CFS symptoms are exacerbated by exercise or stress and occur in the absence of any significant clinical or laboratory findings. The pathology of ME/CFS is not known: it is thought to be multifactorial, resulting from the dysregulation of multiple systems in response to a particular trigger. Although not exclusively considered a post-infectious entity, ME/CFS has been associated with several infectious agents including Epstein–Barr Virus, Q fever, influenza, and other coronaviruses. There are important similarities between post-acute COVID-19 symptoms and ME/CFS. However, there is currently insufficient evidence to establish COVID-19 as an infectious trigger for ME/CFS. Further research is required to determine the natural history of this condition, as well as to define risk factors, prevalence, and possible interventional strategies.
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DOI：
10.1016/j.bbacli.2014.04.001
发表时间：
2014-06-01
期刊：
BBA clinical
影响因子：
--
作者：
Filler, Kristin;Lyon, Debra;Bennett, James;McCain, Nancy;Elswick, Ronald;Lukkahatai, Nada;Saligan, Leorey N
通讯作者：
Saligan, Leorey N
DOI：
10.1016/j.bbi.2010.04.012
发表时间：
2010-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Broderick G;Fuite J;Kreitz A;Vernon SD;Klimas N;Fletcher MA
通讯作者：
Fletcher MA
影响因子：
5.9
作者：
Buchwald, DS;Rea, TD;Ashley, RL
通讯作者：
Ashley, RL
影响因子：
168.9
作者：
COPE, H;DAVID, A;MANN, A
通讯作者：
MANN, A
影响因子：
2.1
作者：
Broderick, G;Craddock, RC;Unger, ER
通讯作者：
Unger, ER